ArticleNeuron2018
The M5 Cell: A Color-Opponent Intrinsically Photosensitive Retinal Ganglion Cell.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed.
- M4-ipRGCs regulate contrast sensitivity in vision.Cell reports · 2026Article
- Simulated natural daylight and twilight modulate activity and light sampling behaviour in mice.BMC biology · 2026Article
- A complete spatial map of mouse retinal ganglion cells reveals density and gene expression specializations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spatial distribution and functional integration of displaced retinal ganglion cells.Scientific reports · 2025Article
- Expression of Osteopontin in M2 and M4 Intrinsically Photosensitive Retinal Ganglion Cells in the Mouse Retina.Investigative ophthalmology & visual science · 2025Article
- Layer-specific anatomical and physiological features of the retina's neurovascular unit.Current biology : CB · 2025Article
- Light-eye-body axis: exploring the network from retinal illumination to systemic regulation.Theranostics · 2025Review
- Article
- Article
- Changes in Intrinsically Photosensitive Retinal Ganglion Cells, Dopaminergic Amacrine Cells, and Their Connectivity in the Retinas of Lid Suture Myopia.Investigative ophthalmology & visual science · 2024Article
- Defining spatial nonuniformities of all ipRGC types using an improved Opn4Cell reports methods · 2024Article
- Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky.bioRxiv : the preprint server for biology · 2024Article
- Flp-recombinase mouse line for genetic manipulation of ipRGCs.bioRxiv : the preprint server for biology · 2024Article
- A newbioRxiv : the preprint server for biology · 2024Article
- Efficacy and specificity of melanopsin reporters for retinal ganglion cells.The Journal of comparative neurology · 2024Article
- Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Colour opponency is widespread across the mouse subcortical visual system and differentially targets GABAergic and non-GABAergic neurons.Scientific reports · 2023Article
- Unusual phototransduction via cross-motif signaling from GProceedings of the National Academy of Sciences of the United States of America · 2023Article
- New insights into retinal circuits through EM connectomics: what we have learnt and what remains to be learned.Frontiers in ophthalmology · 2023Review
- Encephalopsin (OPN3) is required for normal refractive development and the GO/GROW response to induced myopia.Molecular vision · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
Intrinsically photosensitive retinal ganglion cells (ipRGCs) combine direct photosensitivity through melanopsin with synaptically mediated drive from classical photoreceptors through bipolar-cell input. Here, we sought to provide a fuller description of the least understood ipRGC type, the M5 cell, and discovered a distinctive functional characteristic-chromatic opponency (ultraviolet excitatory, green inhibitory). Serial electron microscopic reconstructions revealed that M5 cells receive selective UV-opsin drive from Type 9 cone bipolar cells but also mixed cone signals from bipolar Types 6, 7, and 8. Recordings suggest that both excitation and inhibition are driven by the ON channel and that chromatic opponency results from M-cone-driven surround inhibition mediated by wide-field spiking GABAergic amacrine cells. We show that M5 cells send axons to the dLGN and are thus positioned to provide chromatic signals to visual cortex. These findings underscore that melanopsin's influence extends beyond unconscious reflex functions to encompass cortical vision, perhaps including the perception of color.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.