Circumpapillary microperimetry to detect glaucoma: a pilot study for sector-based comparison to circumpapillary retinal nerve fiber layer measurement.

Yoshiyuki Kita, Gábor Hollό, Tsunehiro Saito, Akiko Murai, Ritsuko Kita, Akito Hirakata

Abstract readComparative Study

In one paragraph

Article in International ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed

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5 citing papers in PubMed.

Pericentral Scotometry Guided by Standard Perimetry Using Microperimetry in Glaucoma Patients.Clinical ophthalmology (Auckland, N.Z.) · 2025
Article
Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans.Translational vision science & technology · 2021
Article
The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes.Clinical ophthalmology (Auckland, N.Z.) · 2021
Article
Correlation of retinal sensitivity in microperimetry with vascular density in optical coherence tomography angiography in primary open-angle glaucoma.PloS one · 2020
Article
Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study.Clinical ophthalmology (Auckland, N.Z.) · 2018
Article

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6 authors.

Yoshiyuki KitaDepartment of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan. kitakita220@gmail.com.

Gábor HollόDepartment of Ophthalmology, Semmelweis University, Budapest, Hungary.

Tsunehiro SaitoDepartment of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

Akiko MuraiDepartment of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

Ritsuko KitaDepartment of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

Akito HirakataDepartment of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate and compare the diagnostic performance of circumpapillary microperimetry (MP) sensitivity and circumpapillary retinal nerve fiber layer thickness (cpRNFLT) measured with optical coherence tomography (OCT) for detection of early to moderate open-angle glaucoma.

methodsEleven eyes (11 patients) with early or moderate open-angle glaucoma and seven normal eyes (7 subjects) underwent MP (MP-3 microperimeter, NIDEK, Japan) and cpRNFLT measurement (RS-3000 Advance OCT, NIDEK, Japan) using an identical circumpapillary circle and similar measurement sectors. The structure-function relationship and the area under the receiver-operating characteristics curve (AUROC) were investigated for each sector, respectively.

resultsSignificant differences (P < 0.05) between glaucoma and normal eyes were found for five of the 12 OCT sectors and seven of the 24 MP sectors. High correlation between cpRNFLT and MP sensitivity was found in the inferotemporal area (OCT sector 5) and superotemporal area (OCT sector 1) (r = 0.818, P < 0.001, and r = 0.796, P < 0.001, respectively). The AUROC values in these sectors ranged 0.890-1.000 for cpRNFLT and 0.825-0.981 for MP sensitivity. Overall, the AUROC ranged 0.506-1.000 for sector cpRNFLT and 0.591-0.981 for sector MP sensitivity.

conclusionsIn this pilot study, circumpapillary MP sensitivity and cpRNFLT showed similar diagnostic power. The structure-function relationship was strong for the superotemporal and inferotemporal circumpapillary areas. Our results suggest that circumpapillary MP represents a new aspect of microperimetry in glaucoma. Further studies on larger populations are necessary to clarify whether the current results are confirmed in clinical practice.

Indexed as

FemaleFollow-Up StudiesGlaucoma, Open-AngleHumansIntraocular PressureMaleMiddle AgedNerve FibersOptic DiskPilot ProjectsReproducibility of ResultsRetinal Ganglion CellsROC CurveSlit Lamp MicroscopyTomography, Optical CoherenceVisual FieldsGlaucomaMicroperimetry sensitivityRetinal nerve fiber layerSpectral-domain optical coherence tomographyStructure–function relationship

Identifiers

PMID29249069

DOI10.1007/s10792-017-0796-8

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