ArticleJournal of neurology2018
Stroke-associated infection independently predicts 3-month poor functional outcome and mortality.
Article in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05998902 (Trophic Enteral Feeding Combined With Supplemental Parenteral Nutrition Treatment in Patients With Severe Stroke), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trophic Enteral Feeding Combined With Supplemental Parenteral Nutrition Treatment in Patients With Severe Stroke (OPENS-2): a Multicentre, Prospective, Randomised, Open-label, Blinded-endpoint Trial
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- C-reactive protein-to-lymphocyte ratio and stroke: associations with prevalence and subsequent mortality in NHANES 1999-2010.Clinical and experimental medicine · 2026Article
- Development of a Novel Prognostic Inflammation Index to Predict Poor Outcomes in Patients With Intracerebral Hemorrhage: A Longitudinal Study.CNS neuroscience & therapeutics · 2026Article
- Early surrogates of functional outcome after thrombectomy for MCA-M2 occlusions.Scientific reports · 2026Article
- Frontiers and literature review on non-aspiration stroke-associated infections.European journal of medical research · 2026Review
- Independent and combined predictive value of nutritional, electrolyte, inflammatory, and insulin resistance indices for post-stroke infection in acute ischemic stroke: a retrospective study.Frontiers in nutrition · 2026Article
- Predicting stroke-associated infection in acute ischemic stroke patients treated by thrombolysis.Frontiers in cellular neuroscience · 2026Article
- Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The predictive implications for stroke-associated infection and prognostic outcome of neutrophil to albumin ratio in Chinese patients with spontaneous intracerebral hemorrhage.Annals of medicine · 2025Article
- Migrasome: a novel insight into unraveling physiological and pathological function.Molecular biology reports · 2025Review
- Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases.Journal of nanobiotechnology · 2025Review
- Stroke-associated pneumonia with low PaOFrontiers in neurology · 2025Article
- Integrating phase-rectified signal averaging with machine learning to predict stroke-associated infections: a retrospective cohort study.Frontiers in neurology · 2025Article
- Six-month survival and predictors of mortality after ischemic stroke: A prospective cohort study in Iran.ARYA atherosclerosis · 2025Article
- Exploring the stroke burden linked to Kidney dysfunction: trends, predictive insights, and health inequalities.Frontiers in neurology · 2025Article
- Association of the Cumulative Inflammatory Index and Long-Term Mortality in Stroke-Associated Pneumonia.Journal of inflammation research · 2025Article
- Migrasomes: key players in immune regulation and promising medical applications.Frontiers in immunology · 2025Review
- Systemic inflammatory response index as a predictor of stroke-associated pneumonia in patients with acute ischemic stroke treated by thrombectomy: a retrospective study.BMC neurology · 2024Article
- Outcomes and risk factors for infection after endovascular treatment in patients with acute ischemic stroke.CNS neuroscience & therapeutics · 2024Article
- A Role for Systemic Inflammation in Stroke-Associated Infection and the Long-Term Prognosis of Acute Ischemic Stroke: A Mediation Analysis.Journal of inflammation research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke-associated infection (SAI) is a common and serious complication of stroke. This study aimed to assess the effects of SAI on patient mortality and functional outcome at 3 months after stroke onset. We retrospectively analyzed 809 consecutive patients with acute stroke (517 men and 292 women; median age, 72 years) who were admitted to our department between September 2014 and June 2016. SAI was defined as an infection diagnosed during the hospitalization period. Poor outcome was defined as a modified Rankin Scale (mRS) score of 3-5 or death (mRS score of 6). The effect of SAI on functional outcome was evaluated using a multivariate logistic regression analysis. SAI occurred in 169 patients (20.9%); of these, 106 (62.7%) had pneumonia, 23 (13.6%) had a urinary-tract infection, and 40 (23.7%) had other types of infection. Patients with SAI were older, more likely to be female, had lower body mass indices, had higher stroke severity, and were more likely to have atrial fibrillation and a history of ischemic heart disease than patients without SAI. Poor functional outcome and mortality were more common in patients with SAI than in patients without SAI (poor functional outcome 41.8 vs. 4.8%, mortality 24.3 vs. 3.9%, respectively). After adjusting for age, sex, stroke severity, and various comorbidities, SAI was independently associated with poor functional outcome [odds ratio (OR) 6.88; 95% confidence interval (CI) 3.72-12.73] and mortality (OR 4.45, 95% CI 2.27-8.72) at 3 months after stroke onset. Our results suggest that SAI during the hospitalization period is independently associated with 3-month poor functional outcome and mortality.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.