Evidence map›Paper›PMID 29249041›Full record

Trial reportJournal of anesthesia2018

Comparison of TIVA with different combinations of ketamine-propofol mixtures in pediatric patients.

Ebru Biricik, Feride Karacaer, Ersel Güleç, Özgür Sürmelioğlu, Murat Ilgınel, Dilek Özcengiz

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of anesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02848963 (Effect of Ketamine-propofol Mixture on Postoperative Pain and Sedation-agitation), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02848963 phase4completednot on this map

Effect of Ketamine-propofol Mixture on Postoperative Pain and Sedation-agitation

TypeinterventionalSponsorCukurova UniversityRan2016 to 2017Enrolled75ConditionsAgitation, Postoperative PainArmsKetamine-propofol mixture
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ebru BiricikDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Cukurova University, 01330, Sarıçam, Adana, Turkey. ebrubiricik01@gmail.com.
Feride KaracaerDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Cukurova University, 01330, Sarıçam, Adana, Turkey.
Ersel GüleçDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Cukurova University, 01330, Sarıçam, Adana, Turkey.
Özgür SürmelioğluDepartment of Head and Neck Surgery, Faculty of Medicine, Çukurova University, Sarıçam, Adana, Turkey.
Murat IlgınelDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Cukurova University, 01330, Sarıçam, Adana, Turkey.
Dilek ÖzcengizDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Cukurova University, 01330, Sarıçam, Adana, Turkey.

Funding

Çukurova Üniversitesi 6177
6 · The paper itself

Abstract

purposeAdding ketamine to propofol has been suggested to be useful for sedation and general anesthesia. This study aimed to determine the effect of TIVA with different ratios of ketofol on recovery in children.

methodsSeventy-five children aged 3-12 years and undergoing adenoidectomy and/or tonsillectomy surgery were randomized into three groups. Ratios of 1:5, 1:6.7 and 1:10 ketamine-propofol mixture (ketofol) were prepared in the same syringe for groups I, II and III, respectively. Induction and maintenance of anesthesia were performed with 1:5, 1:6.7 and 1:10 ratios of ketofol in groups I, II and III, respectively. A McFarlan infusion dose regimen was used (15 mg/kg/h for 15 min, 13 mg/kg/h for 15 min, 11 mg/kg/h for 30 min) and infusion rates were decreased for the different ratios. Infusion rates were reduced to 67, 80 and 90% of the McFarlan dose regimen for groups I, II and III, respectively. Extubating time, length of stay in PACU, postoperative PAED and FLACC scores were recorded.

resultsExtubating time was significantly lower [mean 254.3 ± 92.7 s (95% CI 216.6-292.6, p = 0.001)] in group III than in groups I and II [371.3 ± 153 s (308.1-434.48) and 343.2 ± 123.7 s (292.2-394.3), respectively]. Length of stay in the PACU was lower in group III [median 15 min (interquartile range 15-20, p = 0.001)] than in groups I and II: 20 (15-27.5) and 20 min (20-27.5), respectively.

conclusionTIVA with a 1:10 ratio of ketofol admixture with a 90% reduction of McFarlan regimen can provide improved recovery conditions.

trial registrationClinicalTrials.gov identifier: NCT02848963.

Indexed as

AnesthesiaAnesthetics, IntravenousChildChild, PreschoolDouble-Blind MethodFemaleHumansKetamineMalePostoperative PeriodPropofolProspective StudiesAnesthetics, IntravenousKetaminePropofolKetofolPediatric anesthesiaRecoveryTIVA

Identifiers

PMID29249041

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.