Evidence map›Paper›PMID 29249039›Full record

ReviewCancer chemotherapy and pharmacology2018

Advances in ovarian cancer therapy.

Alexander J Cortez, Patrycja Tudrej, Katarzyna A Kujawa, Katarzyna M Lisowska

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Cancer chemotherapy and pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05793749 (Early Intervention to Prevent Gynecological Malignant Tumors Clinical Study of Lymphedema of the Lower Limbs in Patients With Radiotherapy After Lymphadenectomy), which is not on this map. Cited by 331 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
331citing papers in PubMed, 3 pooled it
55.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05793749 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Early Intervention to Prevent Gynecological Malignant Tumors Clinical Study of Lymphedema of the Lower Limbs in Patients With Radiotherapy After Lymphadenectomy

TypeinterventionalSponsorChongqing University Cancer HospitalRan2023 to 2026Enrolled400ConditionsUterine Cervical Neoplasms, Endometrial Neoplasms, Lymphedema, Treatment EffectivenessArmsProphylactic lymphedema treatment
3 · Its place in the literature

Who cites it

331 citing papers in PubMed, 3 syntheses or guidelines pooled it, 630 citations in OpenAlex.

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  4. Combination of transvaginal ultrasound with cervical cancer screening contributes to early detection of ovarian cancer: Clinical trial.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
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271 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alexander J CortezMaria Skłodowska-Curie Institute - Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, Gliwice, 44-100, Poland.
Patrycja TudrejMaria Skłodowska-Curie Institute - Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, Gliwice, 44-100, Poland.
Katarzyna A KujawaMaria Skłodowska-Curie Institute - Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, Gliwice, 44-100, Poland.
Katarzyna M LisowskaMaria Skłodowska-Curie Institute - Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, Gliwice, 44-100, Poland. katarzyna.lisowska@io.gliwice.pl.ORCID 0000-0001-9786-3993
The Maria Sklodowska-Curie National Research Institute of Oncology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial ovarian cancer is typically diagnosed at an advanced stage. Current state-of-the-art surgery and chemotherapy result in the high incidence of complete remissions; however, the recurrence rate is also high. For most patients, the disease eventually becomes a continuum of symptom-free periods and recurrence episodes. Different targeted treatment approaches and biological drugs, currently under development, bring the promise of turning ovarian cancer into a manageable chronic disease. In this review, we discuss the current standard in the therapy for ovarian cancer, major recent studies on the new variants of conventional therapies, and new therapeutic approaches, recently approved and/or in clinical trials. The latter include anti-angiogenic therapies, polyADP-ribose polymerase (PARP) inhibitors, inhibitors of growth factor signaling, or folate receptor inhibitors, as well as several immunotherapeutic approaches. We also discuss cost-effectiveness of some novel therapies and the issue of better selection of patients for personalized treatment.

Indexed as

Angiogenesis InhibitorsAntineoplastic AgentsClinical Trials as TopicCost-Benefit AnalysisCytoreduction Surgical ProceduresErbB ReceptorsFemaleFolic Acid AntagonistsHumansHyperthermia, InducedImmunotherapyInfusions, ParenteralNeoplasm Recurrence, LocalOvarian NeoplasmsPalliative CarePoly(ADP-ribose) Polymerase InhibitorsAngiogenesis InhibitorsAntineoplastic AgentsErbB ReceptorsFolic Acid AntagonistsPoly(ADP-ribose) Polymerase InhibitorsReceptors, Vascular Endothelial Growth FactorBiological drugsClinical trialsOvarian cancerTargeted therapy

Identifiers

PMID29249039
PMCPMC5754410
OpenAlexW2771491442

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.