Evidence map›Paper›PMID 29249031›Full record

ArticleEnvironmental science and pollution research international2018

Application of protein typing in molecular epidemiological investigation of nosocomial infection outbreak of aminoglycoside-resistant Pseudomonas aeruginosa.

Min Song, Min Tang, Yinghuan Ding, Zecai Wu, Chengyu Xiang, Kui Yang, Zhang Zhang, Baolin Li, Zhenghua Deng, Jinbo Liu

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Infection and drug resistance · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Min SongDepartment of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Min TangDepartment of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Yinghuan DingDepartment of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Zecai WuDepartment of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Chengyu XiangDepartment of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Kui YangDepartment of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Zhang ZhangDepartment of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Baolin LiDepartment of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Zhenghua DengDepartment of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Jinbo LiuDepartment of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, China. liujb7203@163.com.
Affiliated Hospital of Southwest Medical University · CN

Funding

the Fund Project of the Science and Technology leader of Sichuan Province of China 15031the Key Program of National Natural Science Project of China 41130746the National Natural Fund Project of China 41472046the Science and Technology Project of Sichuan Province of China 2016JY0045the Strategic Cooperation Project of the Luzhou people's Government and Sichuan university of China 2013CDLZ-S15
6 · The paper itself

Abstract

Pseudomonas aeruginosan has emerged as an important pathogen elated to serious infections and nosocomial outbreaks worldwide. This study was conducted to understand the prevalence of aminoglycoside (AMG)-resistant P. aeruginosa in our hospital and to provide a scientific basis for control measures against nosocomial infections. Eighty-two strains of P. aeruginosa were isolated from clinical departments and divided into AMG-resistant strains and AMG-sensitive strains based on susceptibility test results. AMG-resistant strains were typed by drug resistance gene typing (DRGT) and protein typing. Five kinds of aminoglycoside-modifying enzyme (AME) genes were detected in the AMG-resistant group. AMG-resistant P. aeruginosa strains were classified into three types and six subtypes by DRGT. Four protein peaks, namely, 9900.02, 7600.04, 9101.25 and 10,372.87 Da, were significantly and differentially expressed between the two groups. AMG-resistant P. aeruginosa strains were also categorised into three types and six subtypes at the distance level of 10 by protein typing. AMG-resistant P. aeruginosa was cloned spread in our hospital; the timely implementation of nosocomial infection prevention and control strategies were needed in preventing outbreaks and epidemic of AMG-resistant P. aeruginosa. SELDI-TOF MS technology can be used for bacterial typing, which provides a new method of clinical epidemiological survey and nosocomial infection control.

Indexed as

AminoglycosidesAnti-Bacterial AgentsBacterial ProteinsBacterial Typing TechniquesCross InfectionDisease OutbreaksDrug Resistance, BacterialHumansMass SpectrometryMicrobial Sensitivity TestsMolecular EpidemiologyPrevalencePseudomonas aeruginosaPseudomonas InfectionsAminoglycosidesAnti-Bacterial AgentsBacterial ProteinsAminoglycoside-modifying enzymesMolecular typingNosocomial infectionPseudomonas aeruginosaResistanceSurface-enhanced laser desorption/ionization-time of flight mass spectrometry

Identifiers

PMID29249031
OpenAlexW2773480397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.