Trial reportIntensive care medicine2018
Prevention of hospital infections by intervention and training (PROHIBIT): results of a pan-European cluster-randomized multicentre study to reduce central venous catheter-related bloodstream infections.
Trial report in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Meta-analysis of the efficacy of taurolidine in reducing catheter-related bloodstream infections for patients receiving parenteral nutrition.JPEN. Journal of parenteral and enteral nutrition · 2022Pooled it
- Hand-hygiene-related clinical trials reported between 2014 and 2020: a comprehensive systematic review.The Journal of hospital infection · 2021Pooled it
- Effect of a novel vital sign device on maternal mortality and morbidity in low-resource settings: a pragmatic, stepped-wedge, cluster-randomised controlled trial.The Lancet. Global health · 2019Trial
- Prevention of arterial catheter-related bloodstream infections: current evidence and future directions.Critical care (London, England) · 2026Review
- Implementation and impact of a business intelligence system on catheter-related bloodstream infections: a multicenter experience.Antimicrobial resistance and infection control · 2025Article
- Skin decontamination to prevent infections in the intensive care unit.Intensive care medicine · 2024Article
- Health care workers' knowledge and perceptions on WHO hand hygiene guidelines, and the perceived barriers to compliance with hand hygiene in Cyprus.BMC nursing · 2024Article
- Safety and efficacy of peripheral metaraminol infusion in patients with neurological conditions: a single-center retrospective observational study.Frontiers in neurology · 2024Article
- Impact of a training strategy on improving compliance of hand hygiene and gloving during the placement of a short peripheral venous catheter: the multicentre study CleanHand4.BMC medical education · 2023Observational
- Implementing strategies to prevent infections in acute-care settings.Infection control and hospital epidemiology · 2023Article
- The effectiveness of a dedicated central venous access care team to prevent catheter-related bloodstream infection in a private hospital.Infection prevention in practice · 2023Article
- Incidence Rate, Pathogens and Economic Burden of Catheter-Related Bloodstream Infection: A Single-Center, Retrospective Case-Control Study.Infection and drug resistance · 2023Article
- Effects of the COVID-19 Pandemic on Incidence and Epidemiology of Catheter-Related Bacteremia, Spain.Emerging infectious diseases · 2022Article
- Hand hygiene improvement of individual healthcare workers: results of the multicentre PROHIBIT study.Antimicrobial resistance and infection control · 2022Article
- Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies.Intensive & critical care nursing · 2022Article
- Microbiological and Clinical Characteristics of Bloodstream Infections in General Intensive Care Unit: A Retrospective Study.Frontiers in medicine · 2022Article
- Reducing central vein catheterization complications with a focused educational program: a retrospective cohort study.Scientific reports · 2020Article
- Expert consensus-based clinical practice guidelines management of intravascular catheters in the intensive care unit.Annals of intensive care · 2020Review
- Sustained effects of a multimodal campaign aiming at hand hygiene improvement on compliance and healthcare-associated infections in a large gynaecology/obstetrics tertiary-care centre in Vietnam.Antimicrobial resistance and infection control · 2020Observational
- Healthcare Associated Infections-A New Pathology in Medical Practice?International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
32 authors at 20 institutions in 16 countries.
Funding
Abstract
purposeTo test the effectiveness of a central venous catheter (CVC) insertion strategy and a hand hygiene (HH) improvement strategy to prevent central venous catheter-related bloodstream infections (CRBSI) in European intensive care units (ICUs), measuring both process and outcome indicators.
methodsAdult ICUs from 14 hospitals in 11 European countries participated in this stepped-wedge cluster randomised controlled multicentre intervention study. After a 6 month baseline, three hospitals were randomised to one of three interventions every quarter: (1) CVC insertion strategy (CVCi); (2) HH promotion strategy (HHi); and (3) both interventions combined (COMBi). Primary outcome was prospective CRBSI incidence density. Secondary outcomes were a CVC insertion score and HH compliance.
resultsOverall 25,348 patients with 35,831 CVCs were included. CRBSI incidence density decreased from 2.4/1000 CVC-days at baseline to 0.9/1000 (p < 0.0001). When adjusted for patient and CVC characteristics all three interventions significantly reduced CRBSI incidence density. When additionally adjusted for the baseline decreasing trend, the HHi and COMBi arms were still effective. CVC insertion scores and HH compliance increased significantly with all three interventions.
conclusionsThis study demonstrates that multimodal prevention strategies aiming at improving CVC insertion practice and HH reduce CRBSI in diverse European ICUs. Compliance explained CRBSI reduction and future quality improvement studies should encourage measuring process indicators.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.