Evidence map›Paper›PMID 29248746›Full record

ArticleAntiviral research2018

Research priorities for the discovery of a cure for chronic hepatitis B: Report of a workshop.

Timothy M Block, Harvey Alter, Nathaniel Brown, Alan Brownstein, Carol Brosgart, Kyong-Mi Chang, Pei-Jer Chen, Chari Cohen, Hashem El-Serag, Jordan Feld and 15 more

Open access · hybridAbstract readConference Proceedings
In one paragraph

Article in Antiviral research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Long-term Hepatitis B and Liver Outcomes Among Adults Taking Tenofovir-Containing Antiretroviral Therapy for HBV/HIV Coinfection in Zambia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  3. Review
  4. Article
  5. Review
  6. Hepatitis B Virus-Associated Hepatocellular Carcinoma and Chronic Stress.International journal of molecular sciences · 2022
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. A global scientific strategy to cure hepatitis B.The lancet. Gastroenterology & hepatology · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 19 institutions in 4 countries.

Timothy M BlockHepatitis B Foundation, Doylestown, PA, USA; Baruch S Blumberg Institute, Doylestown, PA, USA. Electronic address: tim.block@bblumberg.org.
Harvey AlterClinical Center, National Institutes of Health, Bethesda, MD, USA.
Nathaniel BrownHepatitis B Foundation, Doylestown, PA, USA; Baruch S Blumberg Institute, Doylestown, PA, USA.
Alan BrownsteinHepatitis B Foundation, Doylestown, PA, USA.
Carol BrosgartU. California San Francisco School of Medicine and U. California at Berkeley School of Public Health, National Viral Hepatitis Roundtable, USA.
Kyong-Mi ChangUniversity of Pennsylvania School of Medicine and the Philadelphia Veterans Hospital, Philadelphia, PA, USA.
Pei-Jer ChenNational Taiwan University, Taipei, Taiwan.
Chari CohenHepatitis B Foundation, Doylestown, PA, USA; Baruch S Blumberg Institute, Doylestown, PA, USA.
Hashem El-SeragBaylor University College of Medicine, Dallas, TX, USA.
Jordan FeldToronto General Hospital, Toronto, Canada.
Robert GishHepatitis B Foundation, Doylestown, PA, USA; Stanford University Medical Center and Hospital, Palo Alto, CA, USA.
Jeffrey GlennStanford University School of Medicine, Palo Alto, CA, USA.
Tim F GretenNational Cancer Institute, NIH, Bethesda, MD, USA.
Juo-Tao GuoHepatitis B Foundation, Doylestown, PA, USA.
Yujin HoshidaMt. Sinai School of Medicine, New York, NY, USA.
Kris V KowdleySwedish Medical Center, Seattle, WA, USA.
Wenhui LiNational Institute of Biological Sciences, Beijing, China.
Anna S LokUniversity of Michigan School of Medicine, Ann Arbor, MI, USA.
Brian McMahonAlaska Native Medical Center, Anchorage, AK, USA.
Anand MehtaMedical University of South Carolina, Charleston, SC, USA.
Robert PerrilloBaylor University Medical Center, Dallas, TX, USA.
Charles M RiceRockefeller University, New York, NY, USA.
JoAnn RinaudoNational Cancer Institute, NIH, Bethesda, MD, USA.
Raymond F SchinaziEmory University, Atlanta, GA, USA.
Kirti ShettyJohns Hopkins University, Baltimore, MD, USA.
Hepatitis B Foundation · USNational Cancer Institute · USAlaska Native Medical Center · USBaylor University · USBaylor University Medical Center · USEmory University · USHospital of the University of Pennsylvania · USJohns Hopkins University · USMedical University of South Carolina · USMount Sinai Hospital · USNational Institute of Biological Sciences, Beijing · CNNational Institutes of Health Clinical Center · USNational Taiwan University · TWPalo Alto University · USRockefeller University · USStanford Medicine · USSwedish Medical Center · USToronto General Hospital · CAUniversity of Michigan · US

Funding

HBV Capsid EffectorsR01AI132833 · NIAID · EMORY UNIVERSITY · PI Raymond Felix Schinazi · 2017 to 2026
$5.3M
Clinical protocols for the treatment of GI cancerZIABC011343 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GRETEN, TIM · 2010 to 2025
$4.8M
Pathway Specific Functional Biomarkers for the Early Detection of Liver CancerU01CA230690 · NCI · GEORGE WASHINGTON UNIVERSITY · PI MISHRA, LOPA, SHETTY, KIRTI · 2018 to 2022
$3.4M
Intramural NIH HHS Z99 CA999999NCI NIH HHS U01 CA230690NIAID NIH HHS R01 AI132833
6 · The paper itself

Abstract

In early 2017, the Hepatitis B Foundation invited 30 experts in the fields of hepatitis B and liver cancer research to identify projects they deemed important to the goal of finding a cure for chronic hepatitis B and D and the diseases with which these viral infections are associated. They were also asked to identify general categories of research and to prioritize sub-project topics within those areas. The experts generally agreed on broadly defined areas of research, but there was usually little difference between the highest and lowest scoring projects; for the most part, all programs described in this document were considered valuable and necessary. An executive summary of this discussion was recently published (Alter et al., Hepatology 2017). The present manuscript reports the areas of research identified by the workshop participants, provides a brief rationale for their selection, and attempts to express differences among the priorities assigned to each area of research, when such distinctions were expressed.

Indexed as

ResearchAntiviral AgentsHepatitis B, ChronicHepatitis B virusHumansAntiviral AgentsAntiviral therapyHepatitis BHepatitis DHepatocellular carcinoma

Identifiers

PMID29248746
PMCPMC6309822
OpenAlexW2774265441

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.