Evidence map›Paper›PMID 29248635›Full record

ReviewMicrobes and infection

Immunological bases of increased susceptibility to invasive nontyphoidal Salmonella infection in children with malaria and anaemia.

Tonney S Nyirenda, Wilson L Mandala, Melita A Gordon, Pietro Mastroeni

Registry-linked trialAbstract readReview
In one paragraph

Review in Microbes and infection. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07416461 (Effectiveness of Malaria Vaccines in Reducing the Risk of Invasive Non-Typhoidal Salmonella Disease), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07416461 recruitingnot on this map

Effectiveness of Malaria Vaccines in Reducing the Risk of Invasive Non-Typhoidal Salmonella Disease (VINS)

TypeobservationalSponsorInternational Vaccine InstituteRan2025 to 2027Enrolled10,000ConditionsInvasive Non-Typhoidal Salmonella Disease, Malaria, Malaria VaccineArmsR21/Matrix-M malaria vaccine
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Multivalent vaccines for invasiveInfection and immunity · 2026
    Review
  2. Article
  3. Review
  4. Antibiotic-recalcitrant Salmonella during infection.Nature reviews. Microbiology · 2025
    Review
  5. NontyphoidalOpen forum infectious diseases · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Frontiers in cellular and infection microbiology · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Microbes and Infection turns 20.Microbes and infection
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tonney S NyirendaPathology Department, College of Medicine, University of Malawi, Blantyre, Malawi; Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi. Electronic address: tnyirenda@medcol.mw.
Wilson L MandalaMalawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Biomedical Sciences Department, College of Medicine, University of Malawi, Blantyre, Malawi; Academy of Medical Sciences, Malawi University of Science and Technology, Limbe, Malawi.
Melita A GordonMalawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Pietro MastroeniDepartment of Veterinary Medicine, University of Cambridge, United Kingdom.

Funding

Medical Research Council G0001245Wellcome Trust 087547/Z/08/ZWellcome Trust WT087537MA
6 · The paper itself

Abstract

Malaria and anaemia are key underlying factors for iNTS disease in African children. Knowledge of clinical and epidemiological risk-factors for iNTS disease has not been paralleled by an in-depth knowledge of the immunobiology of the disease. Herein, we review human and animal studies on mechanisms of increased susceptibility to iNTS in children.

Indexed as

AnemiaAnimalsChildDisease SusceptibilityHumansMalaria, FalciparumPlasmodium falciparumRisk FactorsSalmonellaSalmonella InfectionsAnaemiaChildrenImmunityMalariaSalmonellaSusceptibility

Identifiers

PMID29248635
PMCPMC6250906

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.