ArticleNeuroscience2018
Inhibiting Mesolimbic Dopamine Neurons Reduces the Initiation and Maintenance of Instrumental Responding.
Article in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Modulation of hierarchical motor sequence learning by alpha-synuclein and the adenosine ANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Phasic dopamine drives conditioned responding beyond its role in learning.bioRxiv : the preprint server for biology · 2026Article
- Dopamine builds and reveals reward-associated latent behavioral attractors.Nature communications · 2024Article
- Enhanced cognitive flexibility and phasic striatal dopamine dynamics in a mouse model of low striatal tonic dopamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- KAddiction biology · 2024Article
- Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior.Cell reports · 2024Article
- Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance.The European journal of neuroscience · 2024Article
- Review
- The Arousal-motor Hypothesis of Dopamine Function: Evidence that Dopamine Facilitates Reward Seeking in Part by Maintaining Arousal.Neuroscience · 2022Article
- Biotechnical development of genetic addiction risk score (GARS) and selective evidence for inclusion of polymorphic allelic risk in substance use disorder (SUD).Journal of systems and integrative neuroscience · 2020Article
- Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking.Journal of neuroscience research · 2020Review
- Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4.Physiology & behavior · 2020Article
- Decreases in Cued Reward Seeking After Reward-Paired Inhibition of Mesolimbic Dopamine.Neuroscience · 2019Article
- Quantity versus quality: Convergent findings in effort-based choice tasks.Behavioural processes · 2019Review
- Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats.eLife · 2019Article
- Oxygen responses within the nucleus accumbens are associated with individual differences in effort exertion in rats.The European journal of neuroscience · 2018Article
- The timing of action determines reward prediction signals in identified midbrain dopamine neurons.Nature neuroscience · 2018Article
- The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation.Pharmacological reviews · 2018Review
- Challenges to Body Fluid Homeostasis Differentially Recruit Phasic Dopamine Signaling in a Taste-Selective Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure.eLife · 2018Article
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Abstract
Mesolimbic dopamine perturbations modulate performance of reward-seeking behavior, with tasks requiring high effort being especially vulnerable to disruption of dopamine signaling. Previous work primarily investigated long-term perturbations such as receptor antagonism and dopamine depletion, which constrain the ability to assess dopamine contributions to effort expenditure in isolation from other behavior events, such as reward consumption. Also unclear is if dopamine is required for both initiation and maintenance when a sequence of multiple instrumental responses is required. Here we used optogenetic inhibition of midbrain TH+ neurons to probe the role of dopamine neuron activity during instrumental responding for reward by varying the time epoch of neural inhibition relative to the time of response initiation. Within a fixed-ratio procedure, requiring eight nosepoke responses per reinforcer delivery, or a progressive ratio (PR) procedure, in which within-session response requirements increased exponentially, inhibiting dopamine neurons while mice were engaged in response bouts decreased the probability of continued responding. If inhibition occurred during each attempted bout, the effect was to decrease total responses, and thus amount of rewards earned, over a session. In contrast, if inhibition was applied only during some bouts, mice increased the number of bouts initiated to earn control levels of reward. Inhibiting dopamine neurons while mice were not responding decreased the probability of initiating an instrumental response but had no effect on the amount of effort exerted over the entire session. We conclude that midbrain dopamine signaling promotes initiation of instrumental responding and maintains motivation to continue ongoing bouts of effortful responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.