ArticleThe American journal of pathology2018
Knockout of l-Histidine Decarboxylase Prevents Cholangiocyte Damage and Hepatic Fibrosis in Mice Subjected to High-Fat Diet Feeding via Disrupted Histamine/Leptin Signaling.
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Article in The American journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Microenvironmental control of the ductular reaction: balancing repair and disease progression.Cell death & disease · 2025Review
- Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity.Cell reports. Medicine · 2023Article
- Ductular reaction in non-alcoholic fatty liver disease: When Macbeth is perverted.World journal of hepatology · 2023Review
- Regulation of metabolic health by dietary histidine in mice.The Journal of physiology · 2023Article
- Maternal Exercise Protects Male Offspring From Maternal Diet-Programmed Nonalcoholic Fatty Liver Disease Progression.Endocrinology · 2023Article
- Histaminergic regulation of food intake.Frontiers in endocrinology · 2023Review
- Article
- A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies.Metabolites · 2022Article
- METTL16-mediated translation ofPeerJ · 2022Article
- Mast cells in liver disease progression: An update on current studies and implications.Hepatology (Baltimore, Md.) · 2022Review
- Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.Hepatology (Baltimore, Md.) · 2021Article
- Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease.Cells · 2021Review
- Mast Cells Promote Nonalcoholic Fatty Liver Disease Phenotypes and Microvesicular Steatosis in Mice Fed a Western Diet.Hepatology (Baltimore, Md.) · 2021Observational
- Biliary Epithelial Senescence in Liver Disease: There Will Be SASP.Frontiers in molecular biosciences · 2021Review
- Association between anti-acid therapies and advanced fibrosis in type 2 diabetics with biopsy-proven non-alcoholic fatty liver disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
- The Dynamic Interplay Between Mast Cells, Aging/Cellular Senescence, and Liver Disease.Gene expression · 2020Review
- Downregulation of p16 Decreases Biliary Damage and Liver Fibrosis in the Mdr2Gene expression · 2020Article
- Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Amelioration of Large Bile Duct Damage by Histamine-2 Receptor Vivo-Morpholino Treatment.The American journal of pathology · 2020Article
- Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2Biochimica et biophysica acta. Molecular basis of disease · 2019Article
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Authors and funding
14 authors at 4 institutions in 1 country.
Lindsey KennedyDepartment of Research, Central Texas Veterans Health Care System, Bryan, Texas; Department of Medical Physiology, Texas A&M Health Science Center, College of Medicine, Bryan, Texas.
Laura HargroveDepartment of Medical Physiology, Texas A&M Health Science Center, College of Medicine, Bryan, Texas.
Jennifer DemievilleDepartment of Research, Central Texas Veterans Health Care System, Bryan, Texas.
Jennifer M BaileyDivision of Gastroenterology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Wasim DarDivision of Immunology and Organ Transplantation, Department of Surgery, University of Texas Health Science Center at Houston, Houston, Texas.
Kishore PolireddyDivision of Gastroenterology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Qingzheng ChenDivision of Gastroenterology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Moises I Nevah RubinDivision of Gastroenterology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Amelia SybengaDepartment of Anatomic and Clinical Pathology, Baylor Scott & White Health, Temple, Texas.
Sharon DeMorrowDepartment of Research, Central Texas Veterans Health Care System, Bryan, Texas; Department of Medical Physiology, Texas A&M Health Science Center, College of Medicine, Bryan, Texas; Department of Research, Baylor Scott & White Health Digestive Disease Research Center, Temple, Texas.
Fanyin MengDepartment of Research, Central Texas Veterans Health Care System, Bryan, Texas; Department of Research, Baylor Scott & White Health Digestive Disease Research Center, Temple, Texas.
Lindsey StocktonDepartment of Research, Baylor Scott & White Health Digestive Disease Research Center, Temple, Texas.
Gianfranco AlpiniDepartment of Research, Central Texas Veterans Health Care System, Bryan, Texas; Department of Medical Physiology, Texas A&M Health Science Center, College of Medicine, Bryan, Texas; Department of Research, Baylor Scott & White Health Digestive Disease Research Center, Temple, Texas.
Heather FrancisDepartment of Research, Central Texas Veterans Health Care System, Bryan, Texas; Department of Medical Physiology, Texas A&M Health Science Center, College of Medicine, Bryan, Texas; Department of Research, Baylor Scott & White Health Digestive Disease Research Center, Temple, Texas. Electronic address: hfrancis@medicine.tamhsc.edu.
Texas A&M Health Science Center · USThe University of Texas Health Science Center at Houston · USBaylor Scott & White Health · USCentral Texas Veterans Health Care System · US
Funding
Dysregulation of hypothalamic neuropeptides is associated with biliary hyperplasiaR01DK082435 · NIDDK · UNIVERSITY OF TEXAS AT AUSTIN · PI DEMORROW, SHARON · 2010 to 2020
$2.7MThe Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and DamageR01DK108959 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FRANCIS, HEATHER L · 2016 to 2024
$2.5MRole of stem cell derived microvesicles in alcoholic liver injuryR21AA025157 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$350kAutocrine/Paracrine Regulation of Intrahepatic Bile Duct GrowthI01BX000574 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2009 to 2022
–Functional characters of non-coding RNAs in alcoholic liver injuryI01BX001724 · VA · RLR VA MEDICAL CENTER · PI MENG, FANYIN · 2012 to 2024
–Mechanisms of synergistic regulation of biliary inflammation and fibrosisI01BX003031 · VA · RLR VA MEDICAL CENTER · PI FRANCIS, HEATHER L · 2016 to 2023
–BLRD VA I01 BX000574BLRD VA I01 BX001724BLRD VA I01 BX003031NIAAA NIH HHS R21 AA025157NIDDK NIH HHS R01 DK082435NIDDK NIH HHS R01 DK108959
Abstract
Feeding a high-fat diet (HFD) coupled with sugar, mimicking a Western diet, causes fatty liver disease in mice. Histamine induces biliary proliferation and fibrosis and regulates leptin signaling. Wild-type (WT) and l-histidine decarboxylase (Hdc
Indexed as
Diet, High-FatAdultAgedAnimalsFemaleHistamineHistidine DecarboxylaseHumansLeptinLiver CirrhosisMaleMiceMice, KnockoutMiddle AgedNon-alcoholic Fatty Liver DiseaseSignal TransductionHistamineHistidine DecarboxylaseLeptin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.