Evidence map›Paper›PMID 29248286›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2018

Perioperative evaluation of regional aortic wall shear stress patterns in patients undergoing aortic valve and/or proximal thoracic aortic replacement.

Emilie Bollache, Paul W M Fedak, Pim van Ooij, Ozair Rahman, S Chris Malaisrie, Patrick M McCarthy, James C Carr, Alex Powell, Jeremy D Collins, Michael Markl and 1 more

Abstract read
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Isolated Ascending Aortic Aneurysms: Five-Year Comparative Outcomes between Modified Wrapping Technique and Supracoronary Tube Replacement.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2026
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  3. Incidence and predictors of continued ascending aortic dilatation after TAVI in patients with bicuspid aortic stenosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Emilie BollacheDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Paul W M FedakDepartment of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Division of Surgery-Cardiac Surgery, Northwestern University, Chicago, Ill.
Pim van OoijDepartment of Radiology, Academic Medical Center, Amsterdam, The Netherlands.
Ozair RahmanDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
S Chris MalaisrieDivision of Surgery-Cardiac Surgery, Northwestern University, Chicago, Ill.
Patrick M McCarthyDivision of Surgery-Cardiac Surgery, Northwestern University, Chicago, Ill.
James C CarrDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Alex PowellDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Jeremy D CollinsDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Michael MarklDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Chicago, Ill.
Alex J BarkerDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill. Electronic address: Alex.barker@northwestern.edu.

Funding

Functional Cardiovascular 4D MRI in Congenital Heart DiseaseR01HL115828 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MARKL, MICHAEL, RIGSBY, CYNTHIA K · 2012 to 2021
$5.2M
Role of Valve-Mediated Hemodynamics on Bicuspid AortopathyR01HL133504 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARKER, ALEXANDER J., FEDAK, PAUL WILLIAM MICHAEL · 2017 to 2021
$2.8M
Hemodynamic Loading of the Left Ventricle and Aorta in Aortic Valve DiseaseK25HL119608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARKER, ALEXANDER J. · 2014 to 2018
$819k
NHLBI NIH HHS K25 HL119608NHLBI NIH HHS R01 HL115828NHLBI NIH HHS R01 HL133504
6 · The paper itself

Abstract

objectivesTo assess in patients with aortopathy perioperative changes in thoracic aortic wall shear stress (WSS), which is known to affect arterial remodeling, and the effects of specific surgical interventions.

methodsPresurgical and postsurgical aortic 4D flow MRI were performed in 33 patients with aortopathy (54 ± 14 years; 5 women; sinus of Valsalva (d_SOV)/midascending aortic (d_MAA) diameters = 44 ± 5/45 ± 6 mm) scheduled for aortic valve (AVR) and/or root (ARR) replacement. Control patients with aortopathy who did not have surgery were matched for age, sex, body size, and d_MAA (n = 20: 52 ± 14 years; 3 women; d_SOV/d_MAA = 42 ± 4/42 ± 4 mm). Regional aortic 3D systolic peak WSS was calculated. An atlas of WSS normal values was used to quantify the percentage of at-risk tissue area with abnormally high WSS, excluding the area to be resected/graft.

resultsPeak WSS and at-risk area showed low interobserver variability (≤0.09 [-0.3; 0.5] Pa and 1.1% [-7%; 9%], respectively). In control patients, WSS was stable over time (follow-up-baseline differences ≤0.02 Pa and 0.0%, respectively). Proximal aortic WSS decreased after AVR (n = 5; peak WSS difference ≤-0.41 Pa and at-risk area ≤-10%, P < .05 vs controls). WSS was increased after ARR in regions distal to the graft (peak WSS difference ≥0.16 Pa and at-risk area ≥4%, P < .05 vs AVR). Follow-up duration had no significant effects on these WSS changes, except when comparing ascending aortic peak WSS between ARR and AVR (P = .006).

conclusionsSerial perioperative 4D flow MRI investigations showed distinct patterns of postsurgical changes in aortic WSS, which included both reductions and translocations. Larger longitudinal studies are warranted to validate these findings with clinical outcomes and prediction of risk of future aortic events.

Indexed as

Aorta, ThoracicAortic ValveCardiac Surgical ProceduresAdultAgedBlood Vessel ProsthesisFemaleHeart Valve DiseasesHeart Valve ProsthesisHemodynamicsHumansMagnetic Resonance AngiographyMaleMiddle AgedPreoperative CareRetrospective Studies4D flow MRIaortic root replacementaortic valve replacementhemiarch repairperioperativewall shear stress

Identifiers

PMID29248286
PMCPMC5955775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.