Trial reportOphthalmology2018
The Primary Tube Versus Trabeculectomy Study: Methodology of a Multicenter Randomized Clinical Trial Comparing Tube Shunt Surgery and Trabeculectomy with Mitomycin C.
Trial report in Ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00666237 (Primary Tube Versus Trabeculectomy Study), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Primary Tube Versus Trabeculectomy Study
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- PreserFlo MicroShunt versus trabeculectomy: an updated meta-analysis and systematic review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Pooled it
- Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study.Ophthalmology · 2024Trial
- Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 5 Years of Follow-up.Ophthalmology · 2022Trial
- Postoperative Complications in the Primary Tube Versus Trabeculectomy Study During 5 Years of Follow-up.Ophthalmology · 2022Trial
- Treatment outcomes in the neovascular glaucoma tube versus trabeculectomy study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Trial
- Outcomes of the Shunt Tube Exposure Prevention Study: A Randomized Clinical Trial.Ophthalmology. GlaucomaTrial
- Lacrimal Drainage Catheter Coated with Mitomycin C to Inhibit Fibrosis after Canalicular Laceration Repair.ACS omega · 2026Article
- The Efficacy and Safety of Minimally Invasive Glaucoma Surgery for Primary Open-Angle Glaucoma: A Systematic Review.Healthcare (Basel, Switzerland) · 2026Review
- Levels of vascular endothelial growth factor and filtration surgery outcomes in diabetic patients with acute primary angle closure.Frontiers in medicine · 2026Article
- Impact of Surgical Sequence on Outcomes of Combined Phacoemulsification and Kahook Dual Blade KDB Goniotomy: A 1-Year Prospective Comparative Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Two-Year Outcomes of Goniotomy After Failed Surgery for Glaucoma: A Multicenter Study.Ophthalmology science · 2026Article
- Early Postoperative Conjunctival Complications Leading to Exposure of Surgically Implanted CorNeat EverPatch Devices.Ophthalmology · 2025Article
- Preserflo MicroShunt versus Trabeculectomy: Efficacy and Surgical Success within a Heterogenous Patient Cohort.Life (Basel, Switzerland) · 2024Article
- Initial Clinical Experience with Ahmed Valve in Romania: Five-Year Patient Follow-Up and Outcomes.Bioengineering (Basel, Switzerland) · 2024Article
- Article
- Long-Term Surgical Outcomes of Glaucoma Drainage Implants in Eyes with Preoperative Intraocular Pressure Less than 19 mmHg.Journal of ophthalmology · 2024Article
- Disparities in Glaucoma Surgery: A Review of Current Evidence and Future Directions for Improvement.Translational vision science & technology · 2023Review
- Minimally Invasive Glaucoma Surgery: A Review of the Literature.Vision (Basel, Switzerland) · 2023Review
- Preserflo microshunt implant for the treatment of refractory uveitic glaucoma: 36-month outcomes.Eye (London, England) · 2023Article
- Double scleral tunnel technique to prevent glaucoma drainage device exposure.European journal of ophthalmology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
purposeTo describe the methodology of the Primary Tube Versus Trabeculectomy (PTVT) Study.
designMulticenter randomized clinical trial.
participantsPatients with medically uncontrolled glaucoma and no prior incisional ocular surgery.
methodsPatients are being enrolled at 16 clinical centers and randomly assigned to treatment with a tube shunt (350-mm
main outcome measuresThe primary outcome measure is the rate of surgical failure, defined as intraocular pressure (IOP) more than 21 mmHg or reduced by less than 20% from baseline, IOP of 5 mmHg or less, reoperation for glaucoma, or loss of light perception vision. Secondary outcome measures include IOP, glaucoma medical therapy, visual acuity, visual fields, and surgical complications.
conclusionsPractice patterns vary in the surgical management of glaucoma, and opinions differ among surgeons regarding the preferred primary operation for glaucoma. The PTVT Study will provide valuable information comparing the 2 most commonly performed glaucoma surgical procedures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.