ArticleCortex; a journal devoted to the study of the nervous system and behavior2018
The role of left insula in executive set-switching: Lesion evidence from an acute stroke cohort.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity.Nature communications · 2026Article
- Disrupted brain network dynamics and cognitive dysfunction in drug-naive major depressive disorder: an EEG microstate study.European archives of psychiatry and clinical neuroscience · 2026Article
- TARGETING INSULO-FRONTAL PATHWAY TO REDUCE STRESS-EVOKED COGNITIVE RIGIDITY.bioRxiv : the preprint server for biology · 2026Article
- Aberrant recruitment of the striatum and insula is associated with recalling and suppressing fatigue- and anger-related memories in people with chronic fatigue syndrome/myalgic encephalomyelitis.Brain communications · 2026Article
- People with HIV exhibit spectrally distinct patterns of rhythmic cortical activity serving cognitive flexibility.Neurobiology of disease · 2024Article
- Involvement of Subinsular Territory Stroke as Predictor of Outcome after Successful Endovascular Recanalization of Left Middle Cerebral Artery Occlusion.Brain sciences · 2024Article
- Processing Speed and Attentional Shift/Mental Flexibility in Patients with Stroke: A Comprehensive Review on the Trail Making Test in Stroke Studies.Neurology international · 2024Review
- Lesion mapping in neuropsychological research: A practical and conceptual guide.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- How distinct functional insular subdivisions mediate interacting neurocognitive systems.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Estimated gray matter volume rapidly changes after a short motor task.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Dissociable language and executive control deficits and recovery in post-stroke aphasia: An exploratory observational and case series study.Neuropsychologia · 2022Observational
- Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults.GeroScience · 2022Article
- Structural brain correlates of burnout severity in medical professionals: A voxel-based morphometric study.Neuroscience letters · 2022Article
- Graph Theoretical Analysis of Structural Covariance Reveals the Relevance of Visuospatial and Attentional Areas in Essential Tremor Recovery After Stereotactic Radiosurgical Thalamotomy.Frontiers in aging neuroscience · 2022Article
- Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder.Frontiers in neuroscience · 2022Article
- Right and left neglect are not anatomically homologous: A voxel-lesion symptom mapping study.Neuropsychologia · 2021Article
- Changes in Brain Electrical Activity According to Post-traumatic Stress Symptoms in Survivors of the Sewol Ferry Disaster: A 1-year Longitudinal Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021Article
- An fMRI Study Using a Combined Task of Interval Discrimination and Oddball Could Reveal Common Brain Circuits of Cognitive Change.Frontiers in psychiatry · 2021Article
- Enriched Rehabilitation Improves Gait Disorder and Cognitive Function in Parkinson's Disease: A Randomized Clinical Trial.Frontiers in neuroscience · 2021Article
- Localization of Brain Networks Engaged by the Sustained Attention to Response Task Provides Quantitative Markers of Executive Impairment in Amyotrophic Lateral Sclerosis.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Impairments in executive functions are common in stroke survivors, both in the acute and in the chronic phase. However, little is known about the underlying lesion neuroanatomy of these deficits. This study aimed to elucidate the pattern of brain damage underlying executive dysfunction in a large and acute stroke cohort. Executive set-switching deficits were evaluated by a shape-based analogue of the Trail Making Test (from the Oxford Cognitive Screen) in a consecutive sample of 144 stroke patients (age: 70 ± 15 years, examination: 5 ± 4 days post-stroke; brain imaging: 1.7 ± 2.9 days post-stroke). A voxelwise lesion-symptom mapping analysis was performed by combining executive set-switching accuracy scores with manually delineated lesions on computerized tomography or magnetic resonance imaging scans. The analysis showed that lesions within the left insular cortex and adjacent white matter predicted poorer executive set-switching. Further analyses confirmed that the lesion effect in the left insula survived correction for the low-level visuospatial and motor component processes of executive set-switching. In conclusion, the study provides lesion-based evidence for the role of the left insular cortex in flexible switching of attention. The findings are consistent with emergent models of insular function postulating the role of this region in regulatory aspects of goal-directed behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.