SynthesisEpilepsy & behavior : E&B2018
ECoG high-gamma modulation versus electrical stimulation for presurgical language mapping.
Synthesis in Epilepsy & behavior : E&B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Naming-related spectral responses predict neuropsychological outcome after epilepsy surgery.Brain : a journal of neurology · 2022Trial
- Article
- Stereo-EEG mapping of visual working memory with task-related high-gamma modulations.Epilepsia · 2026Article
- Prediction of Stimulation-Defined Eloquent Cortex Using Graph-Theoretical Connectivity from Electrocorticography During Presurgical Mapping.bioRxiv : the preprint server for biology · 2026Article
- Review
- Intraoperative Techniques for Language Mapping in Brain Surgery: A Comparison Between Direct Electrical Stimulation (DES) and Electrocorticography (ECoG).Brain and behavior · 2025Review
- The role of neuropsychology in stereo-EEG: A narrative review.Epilepsia open · 2025Review
- Article
- Dynamic Causal Tractography Analysis of Auditory Descriptive Naming: An Intracranial Study of 106 Patients.NeuroImage · 2025Article
- Visualization of functional and effective connectivity underlying auditory descriptive naming.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- High-gamma modulation language mapping and cognitive outcomes after epilepsy surgery.Epilepsia · 2024Article
- Cortical sites critical to language function act as connectors between language subnetworks.Nature communications · 2024Article
- Cortical and white matter substrates supporting visuospatial working memory.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Timing and location of speech errors induced by direct cortical stimulation.Brain communications · 2024Article
- Language lateralization mapping (reversibly) masked by non-dominant focal epilepsy: a case report.Frontiers in human neuroscience · 2023Article
- Dynamic cortical and tractography atlases of proactive and reactive alpha and high-gamma activities.Brain communications · 2023Article
- Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities.Frontiers in human neuroscience · 2023Review
- Intraoperative localization and preservation of reading in ventral occipitotemporal cortex.Journal of neurosurgery · 2022Article
- Inter-individual variability in dorsal stream dynamics during word production.The European journal of neuroscience · 2022Article
- Temporally and functionally distinct large-scale brain network dynamics supporting task switching.NeuroImage · 2022Article
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Funding
Abstract
objectiveThis meta-analysis compared diagnostic validity of electrocorticographic (ECoG) high-γ modulation (HGM) with electrical stimulation mapping (ESM) for presurgical language localization.
methodsFrom a structured literature search, studies with electrode level data comparing ECoG HGM and ESM for language localization were included in the meta-analysis. Outcomes included global measures of diagnostic validity: area under the summary receiver operating characteristic (SROC) curve (AUC), and diagnostic odds ratio (DOR); as well as pooled estimates of sensitivity and specificity. Clinical and technical determinants of sensitivity/specificity were explored.
resultsFifteen studies were included in qualitative synthesis, and 10 studies included in the meta-analysis (number of patients 1-17, mean age 10.3-53.6years). Overt picture naming was the most commonly used task for language mapping with either method. Electrocorticographic high-γ modulation was analyzed at 50-400Hz with different bandwidths in individual studies. For ESM, pulse duration, train duration, and maximum current varied greatly among studies. Sensitivity (0.23-0.99), specificity (0.48-0.96), and DOR (1.45-376.28) varied widely across studies. The pooled estimates are: sensitivity 0.61 (95% CI 0.44, 0.76), specificity 0.79 (95% CI 0.68, 0.88), and DOR 6.44 (95% CI 3.47, 11.94). Area under the SROC curve was 0.77. Results of bivariate meta-regression were limited by small samples for individual variables.
conclusionElectrocorticographic high-γ modulation is a specific but not sensitive method for language localization compared with gold-standard ESM. Given the pooled DOR of 6.44 and AUC of 0.77, ECoG HGM can fairly reliably ascertain electrodes overlying ESM cortical language sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.