Evidence map›Paper›PMID 29247872›Full record

ArticleGenomics, proteomics & bioinformatics2017

Proteomic Analysis Shows Constitutive Secretion of MIF and p53-associated Activity of COX-2

Mandar Dave, Abul B M M K Islam, Roderick V Jensen, Agueda Rostagno, Jorge Ghiso, Ashok R Amin

Open access · goldAbstract read
In one paragraph

Article in Genomics, proteomics & bioinformatics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Macrophage migration inhibitory factor (MIF) controls cytokine release during respiratory syncytial virus infection in macrophages.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Mandar DaveDepartment of Rheumatology, New York University Hospital for Joint Diseases, New York, NY 10003, USA; Department of Science, STEM Division, Union County College, Cranford, NJ 07016, USA.
Abul B M M K IslamDepartment of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka 1000, Bangladesh.
Roderick V JensenDepartment of Biological Sciences, College of Science, Virginia Tech, Blacksburg, VA 24060, USA.
Agueda RostagnoDepartments of Pathology, New York University School of Medicine, New York, NY 10003, USA.
Jorge GhisoDepartments of Pathology, New York University School of Medicine, New York, NY 10003, USA.
Ashok R AminDepartment of Rheumatology, New York University Hospital for Joint Diseases, New York, NY 10003, USA; Departments of Pathology, New York University School of Medicine, New York, NY 10003, USA; Department of Bio-Medical Engineering, Virginia Tech, Blacksburg, VA 24060, USA; RheuMatric Inc., Blacksburg, VA 24061, USA. Electronic address: ashokamin2004@yahoo.com.
New York University · USNew York University Langone Orthopedic Hospital · USUniversity of Dhaka · BDVirginia Tech · USVirginia Tech - Wake Forest University School of Biomedical Engineering & Sciences · US

Funding

Cerebral Amyloidosis and DementiaR01AG030539 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GHISO, JORGE A · 2009 to 2013
$2.2M
CEREBROVASUCLAR AMYLOIDOSIS, STROKE, AND DEMENTIAR01NS051715 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ROSTAGNO, AGUEDA · 2007 to 2011
$1.8M
COX-2 EICOSANOIDS IN ARTHRITISR01AR047206 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ABRAMSON, STEVEN B · 2001 to 2005
$1.5M
NIAMS NIH HHS R01 AR047206NIA NIH HHS R01 AG030539NINDS NIH HHS R01 NS051715
6 · The paper itself

Abstract

The differential expression of two closelyassociated cyclooxygenase isozymes, COX-1 and COX-2, exhibited functions beyond eicosanoid metabolism. We hypothesized that COX-1 or COX-2 knockout lung fibroblasts may display altered protein profiles which may allow us to further differentiate the functional roles of these isozymes at the molecular level. Proteomic analysis shows constitutive production of macrophage migration inhibitory factor (MIF) in lung fibroblasts derived from COX-2

Indexed as

AnimalsArachidonic AcidCarcinogenesisCell LineCyclooxygenase 1Cyclooxygenase 2DinoprostoneFibroblastsIndomethacinInterleukin-1betaIntramolecular OxidoreductasesLungMacrophage Migration-Inhibitory FactorsMembrane ProteinsMice, Inbred C57BLModels, BiologicalArachidonic AcidCyclooxygenase 1Cyclooxygenase 2DinoprostoneIndomethacinInterleukin-1betaIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMembrane ProteinsMif protein, mousePtgs1 protein, mouseRNA, MessengerTumor Suppressor Protein p53CancerCyclooxygenasesMIFp53Proteomics

Identifiers

PMID29247872
PMCPMC5828655
OpenAlexW2724703476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.