ArticlePreventive medicine2018
Is the recent increase in cervical cancer in women aged 20-24years in England a cause for concern?
Article in Preventive medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- The TRIM22-CDT2 axis is the key mediator of the p53-Rb signals in growth control of HPV-positive cervical carcinoma cells.Neoplasia (New York, N.Y.) · 2025Article
- Trends and urban-rural disparities in cervical cancer epidemiology in China, 2005-2018.Scientific reports · 2025Article
- Cervical Cancer Detection Using Deep Neural Network and Hybrid Waterwheel Plant Optimization Algorithm.Bioengineering (Basel, Switzerland) · 2025Article
- Association between HPV vaccination and cervical screening policy changes and cervical cancer incidence and grade-3 cervical intraepithelial neoplasia incidence in England, 2006-2020: a population-based trends analysis.The Lancet regional health. Europe · 2025Article
- Public health concern-driven insights and response of low- and middle-income nations to the World health Organization call for cervical cancer risk eradication.Gynecologic oncology reports · 2024Article
- Effect of the HPV vaccination programme on incidence of cervical cancer and grade 3 cervical intraepithelial neoplasia by socioeconomic deprivation in England: population based observational study.BMJ (Clinical research ed.) · 2024Observational
- Survival rate of cervical cancer: a five year review at a Major Teaching Hospital in Ghana, West Africa.Ecancermedicalscience · 2024Article
- Potential Effects of Age-Based Changes in Screening Guidelines on the Identification of Women at Risk for Developing Cervical Cancer.Cancer prevention research (Philadelphia, Pa.) · 2023Article
- Temporal Changes in Incidence Rates of the Most Common Gynecological Cancers in the Female Population in Central Serbia.Medicina (Kaunas, Lithuania) · 2022Article
- Cues to cervical cancer screening and reaction to cervical cancer diagnosis during screening among women in Shai Osudoku District, Ghana.Ecancermedicalscience · 2022Article
- Impact of changes to cervical screening guidelines on age and interval at which women are tested: Population-based study.Journal of medical screening · 2021Article
- The European response to the WHO call to eliminate cervical cancer as a public health problem.International journal of cancer · 2021Article
- MicroRNA-300 Inhibits the Proliferation and Metastasis of Cervical Cancer Cells via Posttranscriptional Suppression of G Protein-Coupled Receptor 34 (GPR34).Journal of oncology · 2021Article
- Article
- Cancer diagnosis and treatment in the COVID-19 era.European journal of cancer care · 2020Article
- Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.The Lancet. Global health · 2020Article
- circEIF4G2 modulates the malignant features of cervical cancer via the miR‑218/HOXA1 pathway.Molecular medicine reports · 2019Article
- Article
- Starting cervical cancer screening at 25 years of age: the time has come.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The rates of cervical cancer (CxCa) in England among women aged 20-24yrs increased from 2.7 in 2012 to 4.6 per 100,000 in 2014 (p=0.0006). There was concern that the sudden increase was linked to the withdrawal of cervical screening in women aged 20-24 (a policy that affected women born since 1984). We analyse granular data on age and FIGO stage at diagnosis using a generalised linear model to see whether the unprecedented increase in CxCa in young women in 2014 was linked to the change in 2012 to the age at which the first invitation to screening was sent (from 25.0 to 24.5). Annual rates of CxCa per 100,000 women aged 20.0-24.5yrs decreased gradually over time, whereas at age 24.5-25.0yrs they increased from an average of 16 pre-2013 to 49 in 2015. An increase of 20.3 per 100,000 women aged 24.5-25.0yrs (95% CI: 15.2-25.4) was associated with inviting women for screening at age 24.5yrs instead of at age 25.0. At age 25.0-25.5yrs, rates decreased by 23.7 per 100,000 after women were invited at age 24.5yrs (p<0.001). All these changes were limited to stage I CxCa. There was a dramatic increase in diagnoses at age 25yrs in 2009-2011 associated with changing the age at first invitation from 20yrs to 25yrs. No changes were observed at age 26.0-27.0yrs. The increase in CxCa aged 20-24 is attributable to an increase in the proportion of women first screened aged 24.5yrs. The increase was limited to stage I CxCa. There is no evidence of a lack of screening leading to increasing rates.
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