Evidence map›Paper›PMID 29247506›Full record

ArticleClinical pharmacology and therapeutics2018

Suboptimal Antituberculosis Drug Concentrations and Outcomes in Small and HIV-Coinfected Children in India: Recommendations for Dose Modifications.

Benjamin Guiastrennec, Geetha Ramachandran, Mats O Karlsson, A K Hemanth Kumar, Perumal Kannabiran Bhavani, N Poorana Gangadevi, Soumya Swaminathan, Amita Gupta, Kelly E Dooley, Radojka M Savic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical pharmacology and therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Effectiveness and Pharmacokinetic Exposures of First-Line Drugs Used to Treat Drug-Susceptible Tuberculosis in Children: A Systematic Review and Meta-Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Effect of HIV infection on plasma exposure to first-line TB drugs and target attainment in children.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Tuberculosis in children with severe acute malnutrition.Expert review of respiratory medicine · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benjamin GuiastrennecDepartment of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Geetha RamachandranNational Institute for Research in Tuberculosis, Indian Council of Medical Research, Chetpet, Chennai, India.
Mats O KarlssonDepartment of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
A K Hemanth KumarNational Institute for Research in Tuberculosis, Indian Council of Medical Research, Chetpet, Chennai, India.
Perumal Kannabiran BhavaniNational Institute for Research in Tuberculosis, Indian Council of Medical Research, Chetpet, Chennai, India.
N Poorana GangadeviNational Institute for Research in Tuberculosis, Indian Council of Medical Research, Chetpet, Chennai, India.
Soumya SwaminathanNational Institute for Research in Tuberculosis, Indian Council of Medical Research, Chetpet, Chennai, India.
Amita GuptaJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kelly E DooleyJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Radojka M SavicUniversity of California San Francisco, San Francisco, California, USA.

Funding

Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
Innovative PK/PD Approaches to Optimize TBM Treatment in Children (PATCH Study)R01HD074944 · NICHD · JOHNS HOPKINS UNIVERSITY · PI DOOLEY, KELLY E. · 2014 to 2019
$2.5M
NCATS NIH HHS KL2 TR000143NICHD NIH HHS R01 HD074944
6 · The paper itself

Abstract

This work aimed to evaluate the once-daily antituberculosis treatment as recommended by the new Indian pediatric guidelines. Isoniazid, rifampin, and pyrazinamide concentration-time profiles and treatment outcome were obtained from 161 Indian children with drug-sensitive tuberculosis undergoing thrice-weekly dosing as per previous Indian pediatric guidelines. The exposure-response relationships were established using a population pharmacokinetic-pharmacodynamic approach. Rifampin exposure was identified as the unique predictor of treatment outcome. Consequently, children with low body weight (4-7 kg) and/or HIV infection, who displayed the lowest rifampin exposure, were associated with the highest probability of unfavorable treatment (therapy failure, death) outcome (P

Indexed as

CoinfectionDrug Dosage CalculationsModels, BiologicalAdolescentAge FactorsAntitubercular AgentsBody WeightChildChild, PreschoolDose-Response Relationship, DrugDrug Administration ScheduleDrug MonitoringDrug Therapy, CombinationFemaleHIV InfectionsHumansAntitubercular AgentsIsoniazidPyrazinamideRifampin

Identifiers

PMID29247506
PMCPMC6004234

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.