ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2018
Clinical Factors and Postoperative Impact of Bile Leak After Liver Resection.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05705557 (Assessment of Efficacy of ABSOLOK™ Clip System-RFP-2021-01 in Achieving BIliostasis During Parenchymal Transection for Open Liver Resection), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Efficacy of ABSOLOK™ Clip System-RFP-2021-01 in Achieving BIliostasis During Parenchymal Transection for Open Liver Resection
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Risk factors of postoperative bile leakage after liver resection: A systematic review and meta-analysis.Cancer medicine · 2023Pooled it
- Wedge resection versus segment IVb and V resection of the liver for T2 gallbladder cancer: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Systematic review and meta-analysis of the efficacy of prophylactic abdominal drainage in major liver resections.Scientific reports · 2021Pooled it
- Routine White test for earlyBMJ open · 2026Article
- Intraoperative "white test" for bile leak detection during liver resection: a video vignette.Journal of minimally invasive surgery · 2026Article
- A novel bile leak test using contrast-enhanced intraoperative ultrasonic cholangiography in liver resection: a prospective single-arm trial.Surgical endoscopy · 2026Article
- Incidence, patterns and management of complications (90-day-analysis) after liver surgery - a single center experience with 3177 consecutive hepatic resections.Langenbeck's archives of surgery · 2026Article
- Article
- An explainable machine learning model for predicting postoperative cholangitis in pediatric surgical patients with pancreaticobiliary maljunction.BioData mining · 2025Article
- Biliary and respiratory complications after right hepatectomy for hepatocellular carcinoma following selective internal radiation therapy (SIRT): a retrospective case-control study.Hepatobiliary surgery and nutrition · 2025Article
- Endoscopic management of biliary leaks: Where are we now?World journal of gastrointestinal endoscopy · 2025Review
- Imaging and management of complications post biliary-enteric anastomosis.Abdominal radiology (New York) · 2025Review
- Outcomes and Cost of Major Liver Resection Using Combined LigaSure and Stapler: A Propensity Score Matching Study.Journal of clinical medicine · 2025Article
- Risk factors for bile leakage after laparoscopic common bile duct exploration in older patients with choledocholithiasis.World journal of gastrointestinal surgery · 2025Article
- Anatomical Considerations for Biliary Interventions: Navigating Challenging Cases.Seminars in interventional radiology · 2025Review
- Delayed Return of Gastrointestinal Function after Partial Hepatectomy: A Single-Center Cross-Sectional Study.Digestive surgery · 2025Article
- STANDARDIZATION OF THE WHITE TEST IN OPEN LIVER RESECTION: TOWARD NEAR-ZERO CLINICALLY SIGNIFICANT BILE LEAKAGE.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2025Article
- Review
- Preoperative imaging of colorectal liver metastases: what the radiologist and the multidisciplinary team need to know.The British journal of radiology · 2024Review
- Hepatobiliary anastomotic leakage: a narrative review of definitions, grading systems, and consequences of leaks.Translational gastroenterology and hepatology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite technical advances, bile leak remains a significant complication after hepatectomy. The current study uses a targeted multi-institutional dataset to characterize perioperative factors that are associated with bile leakage after hepatectomy to better understand the impact of bile leak on morbidity and mortality.
methodsAdult patients in the 2014-2015 ACS NSQIP targeted hepatectomy dataset were linked to the ACS NSQIP PUF dataset. Bivariable and multivariable regression analyses were used to assess the associations between clinical factors and post-hepatectomy bile leak.
resultsOf 6859 patients, 530 (7.7%) had a postoperative bile leak. Proportion of bile leaks was significantly greater in patients after major compared to minor hepatectomy (12.6 vs. 5.1%, p < 0.001). The proportion of patients with bile leak was significantly greater in patients after major hepatectomy who had concomitant enterohepatic reconstruction (31.8 vs. 10.1%, p < 0.001). Postoperative mortality was significantly greater in patients with bile leaks (6.0 vs. 1.7%, p < 0.001). After adjusting for significant covariates, bile leak was independently associated with increased risk of postoperative morbidity (OR = 4.55; 95% CI 3.72-5.56; p < 0.001). After adjusting for significant effects of postoperative complications, liver failure, and reoperation (all p<0.001), bile leak was not independently associated with increased risk of postoperative mortality (p = 0.262).
conclusionMajor hepatectomy and enterohepatic biliary reconstruction are associated with significantly greater rates of bile leak after liver resection. Bile leak is independently associated with significant postoperative morbidity. Mitigation of bile leak is critical in reducing morbidity and mortality after liver resection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.