Trial reportHernia : the journal of hernias and abdominal wall surgery2018
Full-thickness skin graft vs. synthetic mesh in the repair of giant incisional hernia: a randomized controlled multicenter study.
Trial report in Hernia : the journal of hernias and abdominal wall surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Full-thickness skin and dermal grafts as abdominal wall augmentation in ventral hernia repairs - a systematic review.Hernia : the journal of hernias and abdominal wall surgery · 2026Pooled it
- Association between surgical hernia repair techniques and the incidence of seroma: a systematic review and meta-analysis of randomized controlled trials.Hernia : the journal of hernias and abdominal wall surgery · 2022Pooled it
- Pooled it
- Long-term follow-up of full-thickness skin grafting in giant incisional hernia repair: a randomised controlled trial.Hernia : the journal of hernias and abdominal wall surgery · 2022Trial
- Autologous full-thickness skin graft as reinforcement in parastomal hernia repair: a randomised controlled trial.Trials · 2021Trial
- One-year outcome after repair of giant incisional hernia using synthetic mesh or full-thickness skin graft: a randomised controlled trial.Hernia : the journal of hernias and abdominal wall surgery · 2019Trial
- A scoping review of outcome reporting in randomized controlled trials of incisional and non-incisional ventral hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Case report of an enormous ventral hernia containing a kidney.International journal of surgery case reports · 2025Article
- Are outcomes of giant ventral hernia repair inferior? A propensity-matched analysis.Surgical endoscopy · 2025Article
- A comparative study of full-thickness skin grafting with and without subcutaneous fat preservation.International wound journal · 2023Article
- Autologous full-thickness skin in the repair of complex ventral hernias: an innovative step into the future of complex hernia repair?Frontiers in surgery · 2023Review
- Similar collagen distribution in full-thickness skin grafts in intraperitoneal and onlay positions, an experimental mice-study.Hernia : the journal of hernias and abdominal wall surgery · 2022Article
- Hernia repair using autografts.Hernia : the journal of hernias and abdominal wall surgery · 2022Article
- Could full thickness skin grafts in an onlay position be the new gold standard for incisional hernia repair?Hernia : the journal of hernias and abdominal wall surgery · 2022Article
- Article
- Application of double circular suturing technique (DCST) in repair of giant incision hernias.Annals of translational medicine · 2020Article
- Giant ventral hernia simultaneously containing the spleen, a portion of the pancreas and the left hepatic lobe: A case report.World journal of clinical cases · 2020Article
- The Tensile Strength of Full-Thickness Skin: A Laboratory Study Prior to Its Use as Reinforcement in Parastomal Hernia Repair.Frontiers in surgery · 2019Article
- Comment to: Full thickness skin graft vs. synthetic mesh in the repair of giant incisional hernia: a randomized controlled multicenter study. Clay L, Stark B, Gunnarsson U, Strigård K.Hernia : the journal of hernias and abdominal wall surgery · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRepair of large incisional hernias includes the implantation of a synthetic mesh, but this may lead to pain, stiffness, infection and enterocutaneous fistulae. Autologous full-thickness skin graft as on-lay reinforcement has been tested in eight high-risk patients in a proof-of-concept study, with satisfactory results. In this multicenter randomized study, the use of skin graft was compared to synthetic mesh in giant ventral hernia repair.
methodsNon-smoking patients with a ventral hernia > 10 cm wide were randomized to repair using an on-lay autologous full-thickness skin graft or a synthetic mesh. The primary endpoint was surgical site complications during the first 3 months. A secondary endpoint was patient comfort. Fifty-three patients were included. Clinical evaluation was performed at a 3-month follow-up appointment.
resultsThere were fewer patients in the skin graft group reporting discomfort: 3 (13%) vs. 12 (43%) (p = 0.016). Skin graft patients had less pain and a better general improvement. No difference was seen regarding seroma; 13 (54%) vs. 13 (46%), or subcutaneous wound infection; 5 (20%) vs. 7 (25%). One recurrence appeared in each group. Three patients in the skin graft group and two in the synthetic mesh group were admitted to the intensive care unit.
conclusionNo difference was seen for the primary endpoint short-term surgical complication. Full-thickness skin graft appears to be a reliable material for ventral hernia repair producing no more complications than when using synthetic mesh. Patients repaired with a skin graft have less subjective abdominal wall symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.