Evidence map›Paper›PMID 29247331›Full record

ArticleImmunologic research2018

Polymorphisms in inflammation-related genes and the risk of primary varicose veins in ethnic Russians.

Alexandra Shadrina, Elena Voronina, Mariya Smetanina, Yakov Tsepilov, Kseniya Sevost'ianova, Andrey Shevela, Evgenii Seliverstov, Elena Zakharova, Evgeny Ilyukhin, Alexander Kirienko and 2 more

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Article in Immunologic research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Alexandra ShadrinaInstitute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia. weiner.alexserg@gmail.com.ORCID 0000-0003-1384-3413
Elena VoroninaInstitute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
Mariya SmetaninaInstitute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
Yakov TsepilovNovosibirsk State University, Novosibirsk, Russia.
Kseniya Sevost'ianovaInstitute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
Andrey ShevelaInstitute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
Evgenii SeliverstovPirogov Russian National Research Medical University, Moscow, Russia.
Elena ZakharovaPirogov Russian National Research Medical University, Moscow, Russia.
Evgeny IlyukhinPrivate Surgery Center "Medalp", Saint Petersburg, Russia.
Alexander KirienkoPirogov Russian National Research Medical University, Moscow, Russia.
Igor ZolotukhinPirogov Russian National Research Medical University, Moscow, Russia.
Maxim FilipenkoInstitute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
Novosibirsk State University · RUPirogov Russian National Research Medical University · RUInstitute of Chemical Biology and Fundamental Medicine · RU

Funding

Russian Science Fund 14-15-00734Siberian Branch of the Russian Academy of Sciences Complex scientific program, № II.2П/VI.62-5 0309-2015-0028
6 · The paper itself

Abstract

Inflammation was shown to be activated in varicose veins, although its role in the development of vein wall transformation remains inconclusive. We aimed to investigate the influence of 13 inflammation-related single nucleotide polymorphisms (SNPs) TNF rs1800629 and rs3093661, IL1A rs1800587, IL1RN rs4251961, IL6 rs1800795 and rs1800796, IFNG rs2430561, IL10 rs1800896, TGFB1 rs1800469, HIF1A rs11549465, NFKB1 rs28362491, and rs4648068 on the risk of primary varicose veins (PVVs) in ethnic Russians. We genotyped 709 patients with PVVs and 278 individuals without a history of chronic venous disease and performed a single SNP and a haplotype analysis. Several associations with P < 0.05 were revealed in our study. Variant allele HIF1A rs11549465 T, TNF rs3093661 A, and NFKB1 rs28362491 ATTG deletion showed the reverse association with PVV risk, and allele IL6 rs1800795 C was associated with the increased risk of the studied pathology. Haplotype analysis revealed associations of TNF haplotypes rs3093661 A-rs1800629 G and IL6 rs1800795 C-rs1800796 G with the decreased and the increased risk of PVVs, correspondingly. However, all the observed associations failed to reach statistical significance after the correction for multiple testing, which was set at a level of 10

Indexed as

GenotypeAllelesGenetic Association StudiesGenetic Predisposition to DiseaseHumansHypoxia-Inducible Factor 1, alpha SubunitInflammationInterferon-gammaInterleukin-10Interleukin-1alphaInterleukin 1 Receptor Antagonist ProteinInterleukin-6NF-kappa B p50 SubunitObserver VariationPolymorphism, Single NucleotideRiskHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIFNG protein, humanIL10 protein, humanIL1A protein, humanIL1RN protein, humanIL6 protein, humanInterferon-gammaInterleukin-10Interleukin-1alphaInterleukin 1 Receptor Antagonist ProteinInterleukin-6NF-kappa B p50 SubunitNFKB1 protein, humanTGFB1 protein, humanTransforming Growth Factor beta1Tumor Necrosis Factor-alphaAssociationCytokineInflammationRussiansSingle nucleotide polymorphismVaricose veins

Identifiers

PMID29247331
OpenAlexW2773033502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.