Evidence map›Paper›PMID 29247284›Full record

SynthesisEuropean journal of nuclear medicine and molecular imaging2018

Third-line treatment and

Finn Edler von Eyben, Giandomenico Roviello, Timo Kiljunen, Christian Uprimny, Irene Virgolini, Kalevi Kairemo, Timo Joensuu

Registry-linked trialAbstract readSystematic Review
In one paragraph

Synthesis in European journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322576 (A Phase 2, Single-Arm, Multi-center Study of 177Lu-PSMA), which is not on this map. Cited by 81 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06322576 phase2terminatednot on this mapstarted 2025, after this paper: background citation

A Phase 2, Single-Arm, Multi-center Study of 177Lu-PSMA (177Lu-PNT2002) in Patients With PSMA-Positive Adenoid Cystic Carcinoma

TypeinterventionalSponsorSidney Kimmel Comprehensive Cancer Center at Johns HopkinsRan2025 to 2026Enrolled1ConditionsAdenoid Cystic CarcinomaArms177Lu-PNT2002
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Prospective phase 2 trial of PSMA-targeted molecular RadiothErapy withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Trial
  6. Trial
  7. Outcome-driven dosimetry optimization for [European journal of nuclear medicine and molecular imaging · 2026
    Article
  8. Article
  9. Article
  10. Contemporary review of prognostic markers of prostate cancer from a pathologist perspective.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2025
    Review
  11. Biodistribution and dosimetry of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  12. JHU-2545 preferentially shields salivary glands and kidneys during PSMA-targeted imaging.European journal of nuclear medicine and molecular imaging · 2025
    Article
  13. Article
  14. Article
  15. A Case Report on the Dramatic Response ofCurrent medical imaging · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Finn Edler von EybenCenter of Tobacco Control Research, Birkevej 17, DK 5230, Odense M, Denmark. finn113edler@mail.tele.dk.ORCID 0000-0001-8763-007X
Giandomenico RovielloDepartment of Oncology, Medical Oncology Unit, San Donato Hospital, Arezzo, Italy.
Timo KiljunenDocrates Cancer Center, Helsinki, Finland.
Christian UprimnyDepartment of Nuclear Medicine, University Hospital Innsbruck, Innsbruck, Austria.
Irene VirgoliniDepartment of Nuclear Medicine, University Hospital Innsbruck, Innsbruck, Austria.
Kalevi KairemoDocrates Cancer Center, Helsinki, Finland.
Timo JoensuuDocrates Cancer Center, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThere is a controversy as to the relative efficacy of

methodsThe review followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Searches in Pubmed and Embase selected articles up to September 2017. A search in ClinicalTrials.gov indicated ongoing studies. The meta-analysis used the random-effects model.

resultsTwelve studies including 669 patients reported

conclusionsAs for patients with mCRPC, treatment with

Indexed as

Antigens, SurfaceGlutamate Carboxypeptidase IIHumansLigandsLutetiumMaleNeoplasm MetastasisProstatic Neoplasms, Castration-ResistantRadioisotopesAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IILigandsLutetiumLutetium-177Radioisotopes177Lu-PSMA radioligand therapyAbirateroneCabazitaxelDocetaxelEnzalutamideProstate cancerSystematic review

Identifiers

PMID29247284
PMCPMC5787223

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.