Evidence map›Paper›PMID 29247275›Full record

ArticleNeurochemical research2018

Protective Effect of miR-374a on Chemical Hypoxia-Induced Damage of PC12 Cells In Vitro via the GADD45α/JNK Signaling Pathway.

Weijun Gong, Shuyan Qie, Peiling Huang, Jianing Xi

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Weijun GongDepartment of Neurological Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical University, Xixiazhuang, Badachu Road, Shijingshan District, Beijing, 100144, China.
Shuyan QieDepartment of Neurological Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical University, Xixiazhuang, Badachu Road, Shijingshan District, Beijing, 100144, China.
Peiling HuangBeijing Rehabilitation Medicine Academy, Capital Medical University, Beijing, 100069, China.
Jianing XiDepartment of Neurological Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical University, Xixiazhuang, Badachu Road, Shijingshan District, Beijing, 100144, China. xijn888@sina.com.
Capital Medical University · CNChina Rehabilitation Research Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore the effect of microRNA-374a (miR-374a) on chemical hypoxia-induced pheochromocytoma (PC12) cell damage by mediating growth arrest and the DNA damage-45 alpha (GADD45α)/c-Jun N-terminal kinase (JNK) signaling pathway. PC12 cells were divided into a Control group (no treatment), Model group (treated with CoCl

Indexed as

AnimalsApoptosisCell SurvivalHypoxiaJNK Mitogen-Activated Protein KinasesMAP Kinase Signaling SystemMembrane Potential, MitochondrialMicroRNAsOxidative StressPC12 CellsRatsReactive Oxygen SpeciesJNK Mitogen-Activated Protein KinasesMicroRNAsReactive Oxygen SpeciesGADD45α/JNK signaling pathwayHypoxiaMiR-374aPC12 cells

Identifiers

PMID29247275
OpenAlexW2774658601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.