Evidence map›Paper›PMID 29247211›Full record

ArticleScientific reports2017

Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons.

Ekaterina Pchitskaya, Nina Kraskovskaya, Daria Chernyuk, Elena Popugaeva, Hua Zhang, Olga Vlasova, Ilya Bezprozvanny

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Neuronal Calcium Signaling and Cytoskeletal Dynamics in Neurodegeneration.International journal of molecular sciences · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. L-type CaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. The CaBiomolecules · 2023
    Review
  15. Neuronal Store-Operated Calcium Channels.Molecular neurobiology · 2023
    Review
  16. Article
  17. ER-resident STIM1/2 couples CaProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ekaterina PchitskayaLaboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation.
Nina KraskovskayaLaboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation.
Daria ChernyukLaboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation.
Elena PopugaevaLaboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation.
Hua ZhangDepartment of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX, 75390, USA.
Olga VlasovaLaboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation.
Ilya BezprozvannyLaboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation. Ilya.Bezprozvanny@UTSouthwestern.edu.

Funding

Calcium signaling and synaptic maintenance in Alzheimers diseaseRF1AG055577 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI BEZPROZVANNY, ILYA B, KAVALALI, EGE T · 2017 to 2017
$3.0M
Presenilins and neuronal calcium dyshomeostasisR01NS080152 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI BEZPROZVANNY, ILYA B · 2013 to 2017
$2.3M
NIA NIH HHS RF1 AG055577NINDS NIH HHS R01 NS080152
6 · The paper itself

Abstract

Mushroom spines form strong synaptic contacts and are essential for memory storage. We have previously demonstrated that neuronal store-operated calcium entry (nSOC) in hippocampal neurons is regulated by STIM2 protein. This pathway plays a key role in stability of mushroom spines and is compromised in different mice models of Alzheimer's disease (AD). Actin was thought to be the sole cytoskeleton compartment presented in dendritic spines, however, recent studies demonstrated that dynamic microtubules with EB3 capped plus-ends transiently enter spines. We showed that STIM2 forms an endoplasmic reticulum (ER) Ca

Indexed as

Alzheimer DiseaseAnimalsCalciumCalcium SignalingCells, CulturedDendritic SpinesDisease Models, AnimalGene Knock-In TechniquesHippocampusMiceMice, Inbred C57BLMicrotubule-Associated ProteinsMicrotubulesStromal Interaction Molecule 2SynapsesCalciumEB3 protein, mouseMicrotubule-Associated ProteinsStim2 protein, mouseStromal Interaction Molecule 2

Identifiers

PMID29247211
PMCPMC5732248

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.