ArticleScientific reports2017
Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 3 of them syntheses that pooled it.
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Who cites it
98 citing papers in PubMed, 3 syntheses or guidelines pooled it, 222 citations in OpenAlex.
- What fMRI studies say about the nature of the psychedelic effect: a scoping review.Frontiers in neuroscience · 2025Pooled it
- Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology.Translational psychiatry · 2024Pooled it
- Default Mode Network Modulation by Psychedelics: A Systematic Review.The international journal of neuropsychopharmacology · 2023Pooled it
- Autonomic nervous system activity correlates with peak experiences induced by DMT and predicts increases in well-being.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Psychedelics and the 'inner healer': Myth or mechanism?Journal of psychopharmacology (Oxford, England) · 2024Trial
- Occipital transcranial direct current stimulation in episodic migraine patients: effect on cerebral perfusion.Scientific reports · 2023Trial
- Trial
- Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- The entropic brain today.Brain : a journal of neurology · 2026Review
- Spectral organization of individualized connectome harmonics across brain structure, function and cognition.bioRxiv : the preprint server for biology · 2026Article
- Multiscale structural connectome eigenmodes constrain human brain functional dynamics.Communications biology · 2026Article
- Psychedelic Therapy and the Role of Music: A Scoping Review of Quantitative Evidence on Subjective and Objective Outcomes.Brain and behavior · 2026Article
- Thermodynamic rigidity of harmonic brain states relates to general mental ability in juvenile myoclonic epilepsy.bioRxiv : the preprint server for biology · 2026Article
- Psilocybin shapes the slow, global propagation of brain activity over the cortical layout of 5HT2a receptors.Communications biology · 2026Article
- The role of connectivity for the degeneracy of the brain's resting state dynamics.Journal of computational neuroscience · 2026Article
- Predictors of the Effectiveness of Psychedelics in Treating Depression-A Scoping Review.International journal of molecular sciences · 2026Article
- Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex.Communications biology · 2026Article
- The neuroscience of highly stable, positive, and refined states of consciousness during jhana-type advanced concentration absorption meditation (ACAM-J).bioRxiv : the preprint server for biology · 2025Article
- Connectome harmonics: a novel method exploring the psychedelic experience.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Knocking at the Doors of Perception: Relating LSD Effects on Low‐Frequency Fluctuations and Regional Homogeneity to Receptor Densities in fMRI.The European journal of neuroscience · 2025Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 5 countries.
Funding
Abstract
Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used 'connectome-harmonic decomposition', a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.