ArticleScientific reports2017
Genomic footprints of dryland stress adaptation in Egyptian fat-tail sheep and their divergence from East African and western Asia cohorts.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 95 citations in OpenAlex.
- Article
- Genetic and Epigenetic Adaptation Mechanisms of Sheep Under Multi-Environmental Stress Environment.International journal of molecular sciences · 2025Review
- Genome-wide scan for selection signatures reveals novel insights into the adaptive capacity characteristics in three Chinese cattle breeds.BMC genomics · 2025Article
- Genome-wide scans for signatures of selection in North African sheep reveals differentially selected regions between fat- and thin-tailed breeds.Animal genetics · 2025Article
- History and genetic diversity of African sheep: Contrasting phenotypic and genomic diversity.Animal genetics · 2025Review
- Genomic characteristics of performance traits and adaptation to heat stress in desert Barki sheep.Archives animal breeding · 2025Review
- Effects of heat stress on reproduction and gene expression in sheep.Animal reproduction · 2025Review
- Long-Term Body Weight Trends in Gobra Zebu Cattle Reared at the 'Centre de Recherches Zootechniques' of Dahra (Senegal): A Historical Perspective (1952-2018).Veterinary medicine and science · 2025Article
- Population structure and selection signal analysis of indigenous sheep from the southern edge of the Taklamakan Desert.BMC genomics · 2024Article
- Anthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goats.Scientific reports · 2024Article
- Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits.Genetics, selection, evolution : GSE · 2024Article
- Selection signatures and landscape genomics analysis to reveal climate adaptation of goat breeds.BMC genomics · 2024Article
- Genetic Diversity, Population Structure and Selection Signature in Begait Goats Revealed by Whole-Genome Sequencing.Animals : an open access journal from MDPI · 2024Article
- Refining the genomic profiles of North African sheep breeds through meta-analysis of worldwide genomic SNP data.Frontiers in veterinary science · 2024Article
- Profile of miRNAs induced during sheep fat tail development and roles of four key miRNAs in proliferation and differentiation of sheep preadipocytes.Frontiers in veterinary science · 2024Article
- Insight into the current genomic diversity, conservation status and population structure of Tunisian Barbarine sheep breed.Frontiers in genetics · 2024Article
- Whole-genome resequencing reveals genomic variation and dynamics in Ethiopian indigenous goats.Frontiers in genetics · 2024Article
- Article
- Comprehensive Gene Expression Profiling Analysis of Adipose Tissue in Male Individuals from Fat- and Thin-Tailed Sheep Breeds.Animals : an open access journal from MDPI · 2023Article
- Similar adaptative mechanism but divergent demographic history of four sympatric desert rodents in Eurasian inland.Communications biology · 2023Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
African indigenous sheep are classified as fat-tail, thin-tail and fat-rump hair sheep. The fat-tail are well adapted to dryland environments, but little is known on their genome profiles. We analyzed patterns of genomic variation by genotyping, with the Ovine SNP50K microarray, 394 individuals from five populations of fat-tail sheep from a desert environment in Egypt. Comparative inferences with other East African and western Asia fat-tail and European sheep, reveal at least two phylogeographically distinct genepools of fat-tail sheep in Africa that differ from the European genepool, suggesting separate evolutionary and breeding history. We identified 24 candidate selection sweep regions, spanning 172 potentially novel and known genes, which are enriched with genes underpinning dryland adaptation physiology. In particular, we found selection sweeps spanning genes and/or pathways associated with metabolism; response to stress, ultraviolet radiation, oxidative stress and DNA damage repair; activation of immune response; regulation of reproduction, organ function and development, body size and morphology, skin and hair pigmentation, and keratinization. Our findings provide insights on the complexity of genome architecture regarding dryland stress adaptation in the fat-tail sheep and showcase the indigenous stocks as appropriate genotypes for adaptation planning to sustain livestock production and human livelihoods, under future climates.
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