ArticleAnnals of the rheumatic diseases2018
Preference phenotypes to facilitate shared decision-making in rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Evolving Landscape of Discrete Choice Experiments in Health Economics: A Systematic Review.PharmacoEconomics · 2025Pooled it
- Pooled it
- Systematic review of quantitative preference studies of treatments for rheumatoid arthritis among patients and at-risk populations.Arthritis research & therapy · 2022Pooled it
- Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement: A Cross-sectional Survey Study.Journal of general internal medicine · 2026Article
- Post-operative anticoagulation therapy after knee or hip replacement: The role of patients' preferences in selection of therapy.Research square · 2025Article
- Relative Importance of Disease-Modifying Antirheumatic Drug Attributes for Patients with Rheumatoid Arthritis.Patient preference and adherence · 2025Article
- Physical function and severe side effects matter most to patients with RA (< 5 years): a discrete choice experiment assessing preferences for personalized RA treatment.BMC rheumatology · 2023Article
- A Scalable Service to Improve Health Care Quality Through Precision Audit and Feedback: Proposal for a Randomized Controlled Trial.JMIR research protocols · 2022Article
- Functional capacity vs side effects: treatment attributes to consider when individualising treatment for patients with rheumatoid arthritis.Clinical rheumatology · 2022Article
- Conjoint Analysis: A Research Method to Study Patients' Preferences and Personalize Care.Journal of personalized medicine · 2022Article
- Preferences for Patients with Type 2 Diabetes Mellitus for Medications in Shandong Province, China: A Discrete Choice Experiment.Patient preference and adherence · 2022Article
- Dynamics of Patient-Based Benefit-Risk Assessment of Medicines in Chronic Diseases: A Systematic Review.Patient preference and adherence · 2022Review
- Incorporating Patient Preferences into a Decision-Making Model of Hand Trauma Reconstruction.International journal of environmental research and public health · 2021Article
- A Systematic Review of Discrete Choice Experiment Studies in Rheumatoid Arthritis Biological Medicines.Mediterranean journal of rheumatology · 2021Review
- Benefits of Switch from Oral to Subcutaneous Route on Adherence to Methotrexate in Patients with Rheumatoid Arthritis in Real Life Setting.Patient preference and adherence · 2021Article
- Patient preferences on rheumatoid arthritis second-line treatment: a discrete choice experiment of Swedish patients.Arthritis research & therapy · 2020Article
- New galaxies in the universe of shared decision-making and rheumatoid arthritis.Current opinion in rheumatology · 2020Review
- Shared Decision Making: From Decision Science to Data Science.Medical decision making : an international journal of the Society for Medical Decision Making · 2020Article
- Exploring healthcare professionals' knowledge, attitudes and experiences of shared decision making in rheumatology.RMD open · 2020Article
- Management of rheumatoid arthritis: 2019 updated consensus recommendations from the Hong Kong Society of Rheumatology.Clinical rheumatology · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveImplementing treat-to-target (TTT) strategies requires that patients with rheumatoid arthritis (RA) and their rheumatologists decide on how best to escalate care when indicated. The objective of this study was to develop preference phenotypes to facilitate shared decision-making at the point of care for patients failing methotrexate monotherapy.
methodsWe developed a conjoint analysis survey to measure the preferences of patient with RA for triple therapy, biologics and Janus kinase (JAK) inhibitors. The survey included seven attributes: administration, onset, bothersome side effects, serious infection, very rare side effects, amount of information and cost. Each choice set (n=12) included three hypothetical profiles. Preference phenotypes were identified by applying latent class analysis to the conjoint data.
results1273 participants completed the survey. A five-group solution was chosen based on progressively lower values of the Akaike and Bayesian information criteria. Members of the largest group (group 3: 38.4%) were most strongly impacted by the cost of the medication. The next largest group (group 1: 25.8%) was most strongly influenced by the risk of bothersome side effects. Members of group 2 (11.2%) were also risk averse, but were most concerned with the risk of very rare side effects. Group 4 (6.6%) strongly preferred oral over parenteral medications. Members of group 5 (18.0%) were most strongly and equally influenced by onset of action and the risk of serious infections.
conclusionsTreatment preferences of patients with RA can be measured and represented by distinct phenotypes. Our results underscore the variability in patients' values and the importance of using a shared decision-making approach to implement TTT.
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