ArticleNeurology2018
Prospective study of restless legs syndrome and total and cardiovascular mortality among women.
Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Is Restless Legs Syndrome Associated with an Increased Risk of Mortality? A Meta-Analysis of Cohort Studies.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Pooled it
- Prevalence and treatment response of neuropsychiatric disorders in mast cell activation syndrome.Brain, behavior, & immunity - health · 2025Article
- Spectral EEG and heart rate changes associated with leg movements during the suggested immobilization test in patients with restless legs syndrome.Journal of sleep research · 2025Article
- "Restless Nights, Stressed Hearts": The Link Between Sleep Disorders and Takotsubo Syndrome-A Comprehensive Review.Reviews in cardiovascular medicine · 2025Review
- Prevalence of restless leg syndrome and cutaneous manifestations among nondialysis dependent chronic kidney disease patients.Journal of education and health promotion · 2025Article
- Identification of Causal Genes and Potential Drug Targets for Restless Legs Syndrome: A Comprehensive Mendelian Randomization Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Cardiovascular Implications of Sleep Disorders Beyond Sleep Apnea.Current sleep medicine reports · 2024Article
- Cardiovascular Outcome in Patients with Major Depression: Role of Obstructive Sleep Apnea Syndrome, Insomnia Disorder, and COMISA.Life (Basel, Switzerland) · 2024Article
- High national rates of high-dose dopamine agonist prescribing for restless legs syndrome.Sleep · 2022Article
- Cardiovascular correlates of sleep apnea phenotypes: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).PloS one · 2022Article
- Prognostic Impact of Sleep Patterns and Related-Drugs in Patients with Heart Failure.Journal of clinical medicine · 2021Article
- Cardiac Involvement in Movement Disorders.Movement disorders clinical practice · 2021Review
- Sleep Disturbance, Sleep Disorders and Co-Morbidities in the Care of the Older Person.Medical sciences (Basel, Switzerland) · 2021Review
- Treating Restless Legs Syndrome Was Associated With Low Risk of Cardiovascular Disease: A Cohort Study With 3.4 Years of Follow-Up.Journal of the American Heart Association · 2021Article
- Restless Legs Syndrome: Contemporary Diagnosis and Treatment.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Excessive Daytime Sleepiness and Cardiovascular Mortality in US Adults: A NHANES 2005-2008 Follow-Up Study.Nature and science of sleep · 2021Article
- New onset of restless legs syndrome in pregnancy in a prospective multiracial cohort: Incidence and risk factors.Neurology · 2020Article
- Article
- Restless Legs Syndrome During Pregnancy and 12 Weeks Postpartum and its Links to Cardiovascular Diseases, Stressful Life Events, and Psychiatric History.Journal of clinical medicine · 2020Article
- Why Are Women Prone to Restless Legs Syndrome?International journal of environmental research and public health · 2020Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveWe prospectively examined whether women with physician-diagnosed restless legs syndrome (RLS) had a higher risk of total and cardiovascular disease (CVD) mortality relative to those without RLS.
methodsThe current study included 57,417 women (mean age 67 years) from the Nurses' Health Study without cancer, renal failure, and CVD at baseline (2002). Main outcomes were total and CVD mortality. We used the Cox proportional hazards model to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and CVD-specific mortality based on RLS status, adjusting for age, presence of major chronic diseases, and other potential confounders.
resultsWe documented 6,448 deaths during 10 years of follow-up. We did not observe a significant association between presence of physician-diagnosed RLS and high risk of total mortality (adjusted HR 1.15, 95% CI 0.98-1.34). When cause-specific mortality was studied, participants with RLS had a significantly higher risk of CVD mortality (adjusted HR 1.43, 95% CI 1.02-2.00) relative to those without RLS after adjustment for potential confounders. Longer duration of RLS diagnosis was significantly associated with a higher risk of CVD mortality (
conclusionsWomen with RLS had a higher CVD mortality rate, which may not be fully explained by common co-occurring disorders of RLS.
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Registered trials
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