ArticleLearning & memory (Cold Spring Harbor, N.Y.)2018
Stress leads to aberrant hippocampal involvement when processing schema-related information.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Effects of bogus genetic feedback on subjective and physiological responses to acute stress.Comprehensive psychoneuroendocrinology · 2026Article
- Stress drives the hippocampus to prioritize statistical prediction over episodic encoding.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Propofol differentially modulates the consolidation of schema-related and -unrelated memory.iScience · 2025Article
- An analysis of errors in Chinese-Spanish sight translation by Chinese university students-a corpus study.Frontiers in psychology · 2025Article
- Integrating and fragmenting memories under stress and alcohol.Neurobiology of stress · 2024Article
- Consistently increased dorsolateral prefrontal cortex activity during the exposure to acute stressors.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Stress disrupts insight-driven mnemonic reconfiguration in the medial temporal lobe.NeuroImage · 2023Article
- Metaverse as a possible tool for reshaping schema modes in treating personality disorders.Frontiers in psychology · 2022Article
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Enhancing memory with stress: Progress, challenges, and opportunities.Brain and cognition · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prior knowledge, represented as a mental schema, has critical impact on how we organize, interpret, and process incoming information. Recent findings indicate that the use of an existing schema is coordinated by the medial prefrontal cortex (mPFC), communicating with parietal areas. The hippocampus, however, is crucial for encoding schema-unrelated information but not for schema-related information. A recent study indicated that stress mediators may affect schema-related memory, but the underlying neural mechanisms are currently unknown. Here, we thus tested the impact of acute stress on neural processing of schema-related information. We exposed healthy participants to a stress or control manipulation before they processed, in the MRI scanner, words related or unrelated to a preexisting schema activated by a specific cue. Participants' memory for the presented material was tested 3-5 d after encoding. Overall, the processing of schema-related information activated the mPFC, the precuneus, and the angular gyrus. Stress resulted in aberrant hippocampal activity and connectivity while participants processed schema-related information. This aberrant engagement of the hippocampus was linked to altered subsequent memory. These findings suggest that stress may interfere with the efficient use of prior knowledge during encoding and may have important practical implications, in particular for educational settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.