Evidence map›Paper›PMID 29246942›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Synergistic Targeting of the Regulatory and Catalytic Subunits of PI3Kδ in Mature B-cell Malignancies.

Jeffrey D Cooney, An-Ping Lin, Daifeng Jiang, Long Wang, Avvaru N Suhasini, Jamie Myers, ZhiJun Qiu, Albert Wölfler, Heinz Sill, Ricardo C T Aguiar

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Detecting Förster resonance energy transfer in living cells by conventional and spectral flow cytometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2022
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. PDE4 subtypes in cancer.Oncogene · 2020
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jeffrey D Cooney *Division of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
An-Ping Lin *Division of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Daifeng JiangDivision of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Long WangDivision of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Avvaru N SuhasiniDivision of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Jamie MyersDivision of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
ZhiJun QiuDivision of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Albert WölflerDivision of Hematology, Medical University of Graz, Graz, Austria.
Heinz SillDivision of Hematology, Medical University of Graz, Graz, Austria.
Ricardo C T AguiarDivision of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas. aguiarr@uthscsa.edu.
Medical University of Graz · AT

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
The cyclic AMP/phosphodiesterase4 axis regulates proximal B cell receptor signaling and offers a new therapeutic strategy for B cell lymphomasF30CA206343 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI COONEY, JEFFREY DANIEL · 2016 to 2020
$153k
Post-Translational Control of TET Function in LymphomaI01BX001882 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI AGUIAR, RICARDO C · 2013 to 2025
–
BLRD VA I01 BX001882NCI NIH HHS F30 CA206343NCI NIH HHS P30 CA054174
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AminopyridinesAnimalsAntineoplastic Combined Chemotherapy ProtocolsBenzamidesB-LymphocytesCatalytic DomainCell Line, TumorCell SurvivalClass I Phosphatidylinositol 3-KinasesCyclic Nucleotide Phosphodiesterases, Type 4CyclopropanesDrug RepositioningDrug SynergismHumansLeukemia, Lymphocytic, Chronic, B-CellLymphoma, Large B-Cell, DiffuseAminopyridinesBenzamidesClass I Phosphatidylinositol 3-KinasesCyclic Nucleotide Phosphodiesterases, Type 4CyclopropanesidelalisibPDE4B protein, humanPhosphodiesterase 4 InhibitorsPIK3CD protein, humanProtein Kinase InhibitorsPurinesQuinazolinonesReceptors, Antigen, B-CellRoflumilastSyk KinaseSYK protein, human

Identifiers

PMID29246942
PMCPMC5844841
OpenAlexW2774336059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.