Evidence map›Paper›PMID 29246941›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor.

Gerardo A Vitiello, Benjamin D Medina, Shan Zeng, Timothy G Bowler, Jennifer Q Zhang, Jennifer K Loo, Nesteene J Param, Mengyuan Liu, Alec J Moral, Julia N Zhao and 5 more

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 57 citations in OpenAlex.

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  19. Aspartate and Acetate Fuel Gastrointestinal Stromal Tumors Beyond the Warburg Effect.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Gerardo A VitielloDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Benjamin D MedinaDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Shan ZengDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Timothy G BowlerDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Jennifer Q ZhangDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Jennifer K LooDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Nesteene J ParamDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Mengyuan LiuDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Alec J MoralDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Julia N ZhaoDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Ferdinand RossiDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Cristina R AntonescuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Vinod P BalachandranDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Justin R CrossThe Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, New York.
Ronald P DeMatteoDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York. Ronald.dematteo@uphs.upenn.edu.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Molecular Mechanisms in Gastrointestinal Stromal TumorR01CA102613 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ronald P. Dematteo · 2004 to 2026
$9.2M
SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAMT32CA009501 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Babak J Mehrara · 1985 to 2026
$7.7M
Tyrosine kinase inhibition and immunomodulation for cancerF32CA186534 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ZHANG, JENNIFER Q · 2014 to 2015
$109k
NCI NIH HHS F32 CA186534NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA102613NCI NIH HHS T32 CA009501
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntineoplastic Combined Chemotherapy ProtocolsCell Line, TumorCell SurvivalGastrointestinal NeoplasmsGastrointestinal Stromal TumorsHumansHydrazonesImatinib MesylateMetabolic Networks and PathwaysMice, Inbred NODMice, KnockoutMice, SCIDMitochondriaProtein Kinase InhibitorsTreatment OutcomeHydrazonesImatinib MesylateProtein Kinase InhibitorsTriazolesVLX600

Identifiers

PMID29246941
PMCPMC5815929
OpenAlexW2772014648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.