Evidence map›Paper›PMID 29246939›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Merkel Cell Carcinoma Patients Presenting Without a Primary Lesion Have Elevated Markers of Immunity, Higher Tumor Mutation Burden, and Improved Survival.

Natalie Vandeven, Christopher W Lewis, Vladimir Makarov, Nadeem Riaz, Kelly G Paulson, Daniel Hippe, Amy Bestick, Ryan Doumani, Tessa Marx, Seesha Takagishi and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Paraneoplastic Neurologic Syndromes Associated With Merkel Cell Carcinoma.Neurology(R) neuroimmunology & neuroinflammation · 2024
    Pooled it
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  19. Immune activity in Merkel cell carcinoma.The Journal of dermatology · 2022
    Review
  20. "Present and future of immunotherapy in Neuroendocrine Tumors".Reviews in endocrine & metabolic disorders · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Natalie VandevenDepartment of Medicine (Dermatology), University of Washington, Seattle, Washington.
Christopher W LewisDepartment of Medicine (Dermatology), University of Washington, Seattle, Washington.
Vladimir MakarovHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Nadeem RiazHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Kelly G PaulsonDepartment of Medicine (Dermatology), University of Washington, Seattle, Washington.
Daniel HippeDepartment of Radiology, University of Washington, Seattle, Washington.
Amy BestickDepartment of Medicine (Dermatology), University of Washington, Seattle, Washington.
Ryan DoumaniDepartment of Medicine (Dermatology), University of Washington, Seattle, Washington.
Tessa MarxDepartment of Medicine (Dermatology), University of Washington, Seattle, Washington.
Seesha TakagishiDepartment of Medicine (Dermatology), University of Washington, Seattle, Washington.
Timothy A ChanHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Jaehyuk ChoiDepartment of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Paul NghiemDepartment of Medicine (Dermatology), University of Washington, Seattle, Washington. pnghiem@uw.edu.
University of Washington · USMemorial Sloan Kettering Cancer Center · USNorthwestern University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4M
TRAINING IN CANCER BIOLOGY &TRANSPLANTATIONT32CA009515 · NCI · UNIVERSITY OF WASHINGTON · PI NANCY ELLEN DAVIDSON, Effie W Petersdorf · 1985 to 2026
$16.2M
Environmetal Pathology/Toxicology Training ProgramT32ES007032 · NIEHS · UNIVERSITY OF WASHINGTON · PI FAUSTMAN, ELAINE M, ROSENFELD, MICHAEL E · 1985 to 2023
$10.7M
Pathogenetic and prognostic studies for improved therapy of Merkel cell carcinomaK24CA139052 · NCI · UNIVERSITY OF WASHINGTON · PI NGHIEM, PAUL · 2009 to 2018
$1.8M
Humoral and cellular immunity in polyomavirus-linked Merkel cell carcinomaR01CA162522 · NCI · UNIVERSITY OF WASHINGTON · PI NGHIEM, PAUL · 2011 to 2015
$1.6M
NCI NIH HHS K24 CA139052NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA162522NCI NIH HHS T32 CA009515NIEHS NIH HHS T32 ES007032NIGMS NIH HHS T32 GM007266
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutationAgedBiomarkers, TumorCarcinoma, Merkel CellExome SequencingFemaleHumansImmunotherapyLymphatic MetastasisMaleMiddle AgedSkinSkin NeoplasmsSurvival AnalysisTumor BurdenBiomarkers, Tumor

Identifiers

PMID29246939
PMCPMC5815931
OpenAlexW2772080242

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.