Evidence map›Paper›PMID 29246928›Full record

ArticleRNA (New York, N.Y.)2018

Identification of miR-29b targets using 3-cyanovinylcarbazole containing mimics.

Anupma Choudhary, Darya P Vanichkina, Christine Ender, Joanna Crawford, Gregory J Baillie, Andrew D Calcino, Kelin Ru, Ryan J Taft

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Anupma Choudhary *Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Darya P Vanichkina *Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Christine EnderInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Joanna CrawfordInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Gregory J BaillieInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Andrew D CalcinoDepartment of Integrative Zoology, University of Vienna, Vienna 1090, Austria.
Kelin RuInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Ryan J TaftInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
The University of Queensland · AUAustralian Centre for Disease Preparedness · AUThe University of Sydney · AUUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are highly conserved ∼22 nt small noncoding RNAs that bind partially complementary sequences in target transcripts. MicroRNAs regulate both translation and transcript stability, and play important roles in development, cellular homeostasis, and disease. There are limited approaches available to agnostically identify microRNA targets transcriptome-wide, and methods using miRNA mimics, which in principle identify direct miRNA:transcript pairs, have low sensitivity and specificity. Here, we describe a novel method to identify microRNA targets using miR-29b mimics containing 3-cyanovinylcarbazole (

Indexed as

AnimalsApoptosisApoptosis Regulatory ProteinsArgonaute ProteinsCaenorhabditis elegansCarbazolesCell Cycle ProteinsFocal AdhesionsGTP PhosphohydrolasesHomeobox A10 ProteinsHomeodomain ProteinsHumansMembrane ProteinsMiceMicroRNAsNitrilesAGO2 protein, humanApoptosis Regulatory ProteinsArgonaute ProteinsCarbazolesCell Cycle ProteinsGTP PhosphohydrolasesHomeobox A10 ProteinsHomeodomain ProteinsHOXA10 protein, humanKLF11 protein, humanMembrane ProteinsMicroRNAsMIRN29a microRNA, humanMIRN29 microRNA, mouseNitrilesNRAS protein, humanRepressor ProteinsRNA, AntisenseVinyl Compounds3-cyanovinylcarbazoleCNVKmimicsmiR-29btarget

Identifiers

PMID29246928
PMCPMC5855958
OpenAlexW2771725816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.