Evidence map›Paper›PMID 29246899›Full record

ArticleG3 (Bethesda, Md.)2018

Genetic Identification of Separase Regulators in

Michael Melesse, Dillon E Sloan, Joseph T Benthal, Quincey Caylor, Krishen Gosine, Xiaofei Bai, Joshua N Bembenek

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michael MelesseDepartment of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996.ORCID 0000-0001-5663-9733
Dillon E SloanDepartment of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996.
Joseph T BenthalDepartment of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996.
Quincey CaylorDepartment of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996.
Krishen GosineDepartment of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996.
Xiaofei BaiDepartment of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996.
Joshua N BembenekDepartment of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996 bembenek@utk.edu.ORCID 0000-0002-0966-2268
University of Tennessee at Knoxville · US

Funding

WormBase: a core data resource for C. elegans and other nematodesU41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KERSEY, PAUL, SCHEDL, TIM · 2013 to 2017
$20.5M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Cell Cycle Regulation of Membrane TraffickingR01GM114471 · NIGMS · WAYNE STATE UNIVERSITY · PI BEMBENEK, JOSHUA NATHANIEL · 2015 to 2024
$2.6M
Biotechnology and Biological Sciences Research CouncilMedical Research CouncilNHGRI NIH HHS U41 HG002223NIGMS NIH HHS R01 GM114471NIH HHS P40 OD010440
6 · The paper itself

Abstract

Separase is a highly conserved protease required for chromosome segregation. Although observations that separase also regulates membrane trafficking events have been made, it is still not clear how separase achieves this function. Here, we present an extensive ENU mutagenesis suppressor screen aimed at identifying suppressors of

Indexed as

Gene Expression RegulationAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsMutationNuclear ProteinsPhosphoprotein PhosphatasesProtein BindingSeparaseCaenorhabditis elegans ProteinsNuclear ProteinsPhosphoprotein Phosphatasesprotein phosphatase 5SeparaseC. elegansHSP-90PPH-5separasesuppressors

Identifiers

PMID29246899
PMCPMC5919728
OpenAlexW2951216952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.