ArticleCirculation. Heart failure2017
Hemodynamics of Fontan Failure: The Role of Pulmonary Vascular Disease.
Article in Circulation. Heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- The Effect of Udenafil on Heart Rate and Blood Pressure in Adolescents With the Fontan Circulation.The American journal of cardiology · 2024Trial
- Impact of Udenafil on Echocardiographic Indices of Single Ventricle Size and Function in FUEL Study Participants.Circulation. Cardiovascular imaging · 2022Trial
- Results of the FUEL Trial.Circulation · 2020Trial
- A minimally invasive pre-operative measure of total pulmonary resistance is associated with early adverse outcomes following total cavopulmonary connection.European heart journal. Imaging methods and practice · 2026Article
- Contemporary Management and Future Directions of Adults Living With a Fontan Circulation.JACC. Advances · 2026Review
- Fenestration Re-creation for Early Fontan Deterioration: Long-Term Hemodynamic and Clinical Outcomes.Pediatric cardiology · 2026Article
- Functionally Single-Ventricle Complications After Fontan Palliation-A Narrative Review.Journal of clinical medicine · 2026Review
- A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan-Associated Liver Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Adults with Fontan circulation: prognostic value of exercise pulmonary vascular resistance index.European heart journal · 2026Article
- The fate of the Fontan circulation.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Artificial Intelligence-Enabled ECG for Diastolic Dysfunction in Congenital Heart Disease: A Novel Risk Stratification Tool.JACC. Advances · 2026Article
- New perspectives in the management of adults with congenital heart disease: insights from the 2025 ACHD Congress.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Pulmonary Vascular Endothelial Dysfunction Is Induced by Nonpulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model.Comprehensive Physiology · 2025Article
- Long-Term Outcomes After Fontan Conversion Operation: A Comparative Analysis Based on Type of Fontan Connection.Circulation. Heart failure · 2025Article
- Pulmonary Vascular Endothelial Dysfunction is Induced by Non-Pulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model.bioRxiv : the preprint server for biology · 2025Article
- Mechanical valve replacement in adults with Fontan physiology is an effective palliation in selected patients.International journal of cardiology. Congenital heart disease · 2025Article
- Role of strain imaging for risk stratification in Fontan patients with normal ventricular ejection fraction.European heart journal. Cardiovascular Imaging · 2025Article
- Augmented Biphasic Breathing Using Sniff and an Oral Positive Expiratory Pressure Device (Sniff-PEP) in Fontan Patients.Pediatric cardiology · 2025Article
- Physician Perception of Fontan Failure, "Acceptable" Hemodynamics, Assessment, and Indications for Intervention-Results of a Multinational Survey.CJC pediatric and congenital heart disease · 2025Article
- Randomized, Placebo-Controlled Trial of Peri-Operative Treprostinil in Pediatric Patients Undergoing the Fontan Operation.Pulmonary circulation · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundNonpulsatile pulmonary blood flow in Fontan circulation results in pulmonary vascular disease, but the potential relationships between pulmonary vascular resistance index (PVRI) and Fontan failure have not been studied. The objective was to determine whether the absence of subpulmonary ventricle in the Fontan circulation would make patients more vulnerable to even low-level elevations in PVRI, and when coupled with low cardiac index, this would identify patients at increased risk of Fontan failure. METHODS AND
resultsTwo hundred sixty-one adult Fontan patients underwent cardiac catheterization; age 26±3 years, men 146 (56%), atriopulmonary Fontan 144 (55%). Patients were divided into 2 groups: those with high PVRI (>2 WU·m
conclusionsWhen coupled with low cardiac index, even mild elevations in PVRI identify patients at high risk of Fontan failure. This suggests that pulmonary vascular disease is a key mechanism underlying Fontan failure and supports further studies to understand the pathophysiology and target treatments to pulmonary vascular tone in this population.
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