Evidence map›Paper›PMID 29246856›Full record

ReviewNeuropharmacology2018

The behavioral pharmacology and therapeutic potential of lorcaserin for substance use disorders.

Gregory T Collins, Lisa R Gerak, Charles P France

Abstract readReview
In one paragraph

Review in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. The 5-HTPharmacology research & perspectives · 2021
    Trial
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Learning from lorcaserin: lessons from the negative clinical trial of lorcaserin to treat cocaine use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Review
  15. Article
  16. Article
  17. Review
  18. Ligand-directed serotonin 5-HTEuropean journal of pharmacology · 2019
    Article
  19. Article
  20. Impaired cognitive behavioral flexibility following methamphetamine or high caloric diet consumption: a common 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Gregory T CollinsDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; South Texas Veterans Health Care System, San Antonio, TX 78229, USA; Addiction Research, Treatment & Training Center of Excellence, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Lisa R GerakDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Addiction Research, Treatment & Training Center of Excellence, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Charles P FranceDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Addiction Research, Treatment & Training Center of Excellence, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Electronic address: france@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · US

Funding

DISCRIMINATIVE STIMULUS OF OPIOID WITHDRAWALR01DA005018 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FRANCE, CHARLES P · 1988 to 2025
$8.8M
Training in Drug Abuse Research: Behavior and NeurobiologyT32DA031115 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHARLES P FRANCE · 2011 to 2026
$5.2M
Behavioral Pharmacology of Drug DependenceK05DA017918 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FRANCE, CHARLES P · 2005 to 2014
$1.2M
Evaluation of the 5-HT2C agonist lorcaserin as potential treatment for cocaine abU01DA034992 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FRANCE, CHARLES P · 2013 to 2015
$722k
NIDA NIH HHS K05 DA017918NIDA NIH HHS R01 DA005018NIDA NIH HHS T32 DA031115NIDA NIH HHS U01 DA034992
6 · The paper itself

Abstract

Substance abuse is serious public health problem for which there are few effective pharmacotherapies. Traditional strategies for drug development have focused on antagonists to block the abuse-related effects of a drug at its site of action, and agonists to replace/mimic the effects of the abused substance. However, recent efforts have targeted receptors, such as serotonin (5-HT)

Indexed as

AnimalsBenzazepinesHumansPsychotropic DrugsSubstance-Related DisordersBenzazepineslorcaserinPsychotropic DrugsDrug abuseLorcaserinSelf-administrationSerotonin 2C receptor

Identifiers

PMID29246856
PMCPMC5997497
OpenAlexW2771506208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.