ArticleHeart rhythm2018
Hyperspectral imaging for label-free in vivo identification of myocardial scars and sites of radiofrequency ablation lesions.
Article in Heart rhythm, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Medical hyperspectral imaging: an updated review of technology advancements and biomedical applications.Journal of biomedical optics · 2026Pooled it
- Panoramic hyperspectral optical mapping of cardiac membrane potential and tissue type.Journal of biomedical optics · 2026Article
- Side-viewing probe for lesion depth mapping on the left ventricle epicardium with near-infrared spectroscopy.Scientific reports · 2026Article
- Multimodal PSOCT-NIRS catheter for guided ablation of atrial fibrillation.Journal of biomedical optics · 2026Article
- Image-Based Monitoring of Thermal Ablation.Bioengineering (Basel, Switzerland) · 2025Review
- Monitoring of irrigated lesion formation with single fiber based multispectral system using machine learning.Journal of biophotonics · 2022Article
- Analysis of muscle tissue in vivo using fiber-optic autofluorescence and diffuse reflectance spectroscopy.Journal of biomedical optics · 2021Article
- Quantification of irrigated lesion morphology using near-infrared spectroscopy.Scientific reports · 2021Article
- Hyperspectral Imagery for Assessing Laser-Induced Thermal State Change in Liver.Sensors (Basel, Switzerland) · 2021Article
- A Percutaneous Catheter for In Vivo Hyperspectral Imaging of Cardiac Tissue: Challenges, Solutions and Future Directions.Cardiovascular engineering and technology · 2020Review
- Autofluorescence properties of balloon polymers used in medical applications.Journal of biomedical optics · 2020Article
- Towards real-time multispectral endoscopic imaging for cardiac lesion quality assessment.Biomedical optics express · 2019Article
- Real-time optical spectroscopic monitoring of nonirrigated lesion progression within atrial and ventricular tissues.Journal of biophotonics · 2019Article
- Application of unsupervised learning to hyperspectral imaging of cardiac ablation lesions.Journal of medical imaging (Bellingham, Wash.) · 2018Article
- Optimization of wavelength selection for multispectral image acquisition: a case study of atrial ablation lesions.Biomedical optics express · 2018Article
- Lights on! Can visual light help distinguish fibrotic scars from ablation lesions?Heart rhythm · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTreatment of cardiac arrhythmias often involves ablating viable muscle tissue within or near islands of scarred myocardium. Yet, today there are limited means by which the boundaries of such scars can be visualized during surgery and distinguished from the sites of acute injury caused by radiofrequency (RF) ablation.
objectiveWe sought to explore a hyperspectral imaging (HSI) methodology to delineate and distinguish scar tissue from tissue injury caused by RF ablation.
methodsRF ablation of the ventricular surface of live rats that underwent thoracotomy was followed by a 2-month animal recovery period. During a second surgery, new RF lesions were placed next to the scarred tissue from the previous ablation procedure. The myocardial infarction model was used as an alternative way to create scar tissue.
resultsExcitation-emission matrices acquired from the sites of RF lesions, scar region, and the surrounding unablated tissue revealed multiple spectral changes. These findings justified HSI of the heart surface using illumination with 365 nm UV light while acquiring spectral images within the visible range. Autofluorescence-based HSI enabled to distinguish sites of RF lesions from scar or unablated myocardium in open-chest rats. A pilot version of a percutaneous HSI catheter was used to demonstrate the feasibility of RF lesion visualization in atrial tissue of live pigs.
conclusionHSI based on changes in tissue autofluorescence is a highly effective tool for revealing-in vivo and with high spatial resolution-surface boundaries of myocardial scar and discriminating it from areas of acute necrosis caused by RF ablation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.