ReviewHeart rhythm2018
The pathophysiology of the vasovagal response.
Review in Heart rhythm, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 150 citations in OpenAlex.
- Sensor detection and pacing for impending reflex syncope.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Review
- Cardioneuroablation: A Comprehensive Review.Reviews in cardiovascular medicine · 2026Review
- Unexpected Cardiac Asystole Caused by Vasovagal Reaction During Venipuncture: A Case Report.Clinical practice and cases in emergency medicine · 2026Article
- Pediatric syncope in the emergency department: a risk-stratified diagnostic and disposition pathway.International journal of emergency medicine · 2026Review
- Risk Factors for Vasovagal Reactions during Nonoperative Orthopedic Interventions in Outpatient Clinics: A Clinical Evaluation of 1,208 Patients.Clinics in orthopedic surgery · 2026Article
- Recurrent syncope with seizure-like features: the role of emergency monitoring in revealing intermittent AV block.International journal of emergency medicine · 2026Article
- Physiological correlates and predictors of vasovagal responses following dry needling in myofascial pain syndrome: a controlled observational study.Therapeutic advances in musculoskeletal disease · 2026Article
- Now is the time to take syncope seriously.The British journal of cardiology · 2026Article
- Analysis of Clinical Features in Children with Vasovagal Syncope Complicated by Convulsions or Incontinence.Biomedicines · 2025Article
- Progressive baroreflex dysfunction and hypotension preceding VVS: a vicious cycle?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Stretch-induced blood pressure moderation: A potential basis for the sense of well-being accompanying stretching of upper back and neck muscles.Physiological reports · 2025Article
- Eagle syndrome presenting with cardiac sinoatrial arrest and recurrent syncope.BMJ case reports · 2025Article
- Recurrent postcoital syncope due to a vagal response triggered by deep penetration: a case report.Annals of medicine and surgery (2012) · 2025Article
- The clinical role of closed loop stimulation pacemakers in the treatment of patients with sinus node dysfunction: a review.Future cardiology · 2025Review
- Guanfacine for Treatment of Anxiety and Panic-Induced Vasovagal Syncope in the Intensive Care Unit.Cureus · 2025Article
- Features of Clinical Manifestations and Heart Rate Variability in Children with Malignant Vasovagal Syncope.Children (Basel, Switzerland) · 2025Article
- Haemodynamic Patterns in Reflex Syncope: Insights from Head-Up Tilt Tests in Adults and Children.Journal of clinical medicine · 2025Article
- Endocardial autonomic denervation of the left atrium to treat recurrent micturition syncope.HeartRhythm case reports · 2025Article
- Mesenteric blood flow and muscle sympathetic nerve activity during vasovagal syncope.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Evaluation of the clinical value of heart rate variability in predicting vasovagal syncope.Frontiers in cardiovascular medicine · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 6 countries.
Funding
Abstract
In part I of this study, we found that the classical studies on vasovagal syncope, conducted in fit young subjects, overstated vasodilatation as the dominant hypotensive mechanism. Since 1980, blood pressure and cardiac output have been measured continuously using noninvasive methods during tilt, mainly in patients with recurrent syncope, including women and the elderly. This has allowed us to analyze in more detail the complex sequence of hemodynamic changes leading up to syncope in the laboratory. All tilt-sensitive patients appear to progress through 4 phases: (1) early stabilization, (2) circulatory instability, (3) terminal hypotension, and (4) recovery. The physiology responsible for each phase is discussed. Although the order of phases is consistent, the time spent in each phase may vary. In teenagers and young adults, progressive hypotension during phases 2 and 3 can be driven by vasodilatation or falling cardiac output. The fall in cardiac output is secondary to a progressive decrease in stroke volume because blood is pooled in the splanchnic veins. In adults a fall in cardiac output is the dominant hypotensive mechanism because systemic vascular resistance always remains above baseline levels.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.