ArticleBrain stimulation
Impact of brain shift on subcallosal cingulate deep brain stimulation.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Robustness of Lead Reconstruction for Deep Brain Stimulation Modeling and Probabilistic Mapping.Stereotactic and functional neurosurgery · 2026Article
- Brainshift correction using navigated intraoperative ultrasound informs intraoperative decision-making during glioma surgery.Acta neurochirurgica · 2025Article
- The Related Factors and Effect of Electrode Displacement on Motor Outcome of Subthalamic Nuclei Deep Brain Stimulation in Parkinson's Disease.Journal of clinical medicine · 2023Article
- MER and increased operative time are not risk factors for the formation of pneumocephalus during DBS.Scientific reports · 2023Article
- Impact of brain shift on neural pathways in deep brain stimulation: a preliminary analysis via multi-physics finite element models.Journal of neural engineering · 2021Article
- StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson's Disease.Neuromodulation : journal of the International Neuromodulation Society · 2021Article
- Pneumocephalus in subthalamic deep brain stimulation for Parkinson's disease: a comparison of two different surgical techniques considering factors conditioning brain shift and target precision.Acta neurochirurgica · 2021Article
- Early Deformation of Deep Brain Stimulation Electrodes Following Surgical Implantation: Intracranial, Brain, and Electrode Mechanics.Frontiers in bioengineering and biotechnology · 2021Article
- A Decade of Progress in Deep Brain Stimulation of the Subcallosal Cingulate for the Treatment of Depression.Journal of clinical medicine · 2020Review
- Deep Brain Stimulation Is Effective for Treatment-Resistant Depression: A Meta-Analysis and Meta-Regression.Journal of clinical medicine · 2020Article
- Techniques for pneumocephalus and brain shift reduction in DBS surgery: a review of the literature.Neurosurgical review · 2020Review
- Deep Brain Stimulation Initiative: Toward Innovative Technology, New Disease Indications, and Approaches to Current and Future Clinical Challenges in Neuromodulation Therapy.Frontiers in neurology · 2020Review
- Physical Plasticity of the Brain and Deep Brain Stimulation Lead: Evolution in the First Post-operative Week.Frontiers in surgery · 2020Article
- Stereoelectroencephalography in epilepsy, cognitive neurophysiology, and psychiatric disease: safety, efficacy, and place in therapy.Neuropsychiatric disease and treatment · 2019Review
- ESM-CT: a precise method for localization of DBS electrodes in CT images.Journal of neuroscience methods · 2018Article
- Image-based biophysical modeling predicts cortical potentials evoked with subthalamic deep brain stimulation.Brain stimulationArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDeep brain stimulation (DBS) of the subcallosal cingulate (SCC) is an emerging experimental therapy for treatment-resistant depression. New developments in SCC DBS surgical targeting are focused on identifying specific axonal pathways for stimulation that are estimated from preoperatively collected diffusion-weighted imaging (DWI) data. However, brain shift induced by opening burr holes in the skull may alter the position of the target pathways.
objectivesQuantify the effect of electrode location deviations on tractographic representations for stimulating the target pathways using longitudinal clinical imaging datasets.
methodsPreoperative MRI and DWI data (planned) were coregistered with postoperative MRI (1 day, near-term) and CT (3 weeks, long-term) data. Brain shift was measured with anatomical control points. Electrode models corresponding to the planned, near-term, and long-term locations were defined in each hemisphere of 15 patients. Tractography analyses were performed using estimated stimulation volumes as seeds centered on the different electrode positions.
resultsMean brain shift of 2.2 mm was observed in the near-term for the frontal pole, which resolved in the long-term. However, electrode displacements from the planned stereotactic target location were observed in the anterior-superior direction in both the near-term (mean left electrode shift: 0.43 mm, mean right electrode shift: 0.99 mm) and long-term (mean left electrode shift: 1.02 mm, mean right electrode shift: 1.47 mm). DBS electrodes implanted in the right hemisphere (second-side operated) were more displaced from the plan than those in the left hemisphere. These displacements resulted in 3.6% decrease in pathway activation between the electrode and the ventral striatum, but 2.7% increase in the frontal pole connection, compared to the plan. Remitters from six-month chronic stimulation had less variance in pathway activation patterns than the non-remitters.
conclusionsBrain shift is an important concern for SCC DBS surgical targeting and can impact connectomic analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.