Evidence map›Paper›PMID 29246467›Full record

Trial reportThe Journal of pediatrics2018

A Randomized Clinical Trial of Umbilical Cord Milking vs Delayed Cord Clamping in Preterm Infants: Neurodevelopmental Outcomes at 22-26 Months of Corrected Age.

Anup Katheria, Donna Garey, Giang Truong, Natacha Akshoomoff, Jane Steen, Mauricio Maldonado, Debra Poeltler, Mary Jane Harbert, Yvonne E Vaucher, Neil Finer

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01434732 nacompletednot on this map

A Randomized Controlled Trial of Umbilical Cord Milking Versus Immediate Cord Clamping on Systemic Blood Flow in Premature Infants

TypeinterventionalSponsorSharp HealthCareRan2011 to 2013Enrolled60ConditionsAbnormal Vascular FlowArmsUmbilical Cord Milking, Immediate Cord Clamping
NCT01866982 nacompletednot on this map

The PREMOD Trial: A Randomized Controlled Trial of Umbilical Cord Milking vs. Delayed Cord Clamping in Premature Infants

TypeinterventionalSponsorSharp HealthCareRan2013 to 2018Enrolled197ConditionsIntraventricular HemorrhageArmsUmbilical Cord Milking, Delayed Cord Clamping
NCT03476980 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Two Year Developmental Follow-up for Premature Infants Receiving Milking or Delayed Cord Clamping: PREMOD2

TypeinterventionalSponsorSharp HealthCareRan2019 to 2024Enrolled1,200ConditionsNeurodevelopmental AbnormalityArmsRandomized to Umbilical Cord Milking at birth, Randomized to Delayed Cord Clamping at birth
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Trial
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  11. Umbilical cord milking for neonates who are depressed at birth: a randomized trial of feasibility.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Trial
  12. Article
  13. Article
  14. Article
  15. Cord management in non-vigorous newborns.Seminars in perinatology · 2023
    Article
  16. Article
  17. Article
  18. Umbilical cord milking-benefits and risks.Frontiers in pediatrics · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anup KatheriaNeonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA. Electronic address: anup.katheria@sharp.com.
Donna GareyNeonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA; Department of Pediatrics, Columbia University, New York, NY.
Giang TruongDepartment of Pediatrics, Loma Linda University Medical Center, Loma Linda, CA.
Natacha AkshoomoffDepartment of Psychiatry, University of California, San Diego, San Diego, CA.
Jane SteenNeonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA.
Mauricio MaldonadoNeonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA.
Debra PoeltlerNeonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA.
Mary Jane HarbertNeonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA.
Yvonne E VaucherDepartment of Pediatrics, University of California, San Diego, San Diego, CA.
Neil FinerNeonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA; Department of Pediatrics, University of California, San Diego, San Diego, CA.

Funding

Neural Basis of Emergent Math Difficulties in Healthy Preterm ChildrenR01HD075865 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKSHOOMOFF, NATACHA · 2013 to 2017
$3.0M
Evaluation of Umbilical Cord Milking on Systemic Blood Flow in Premature InfantsR03HD072934 · NICHD · SHARP MEMORIAL HOSPITAL · PI KATHERIA, ANUP C · 2013 to 2014
$126k
NICHD NIH HHS R03 HD072934
6 · The paper itself

Abstract

objectiveTo compare the effect of umbilical cord milking vs delayed cord clamping (DCC) on neurodevelopmental and health outcomes in very preterm infants at 22-26 months of corrected age. STUDY

designNeurodevelopmental outcomes at 2 years of age were assessed using the Bayley Scales of Infant Development, third edition, and a standardized neurologic examination. Data regarding pulmonary morbidities, neurosensory impairments, and hospitalizations were obtained by parental interview. Intention-to-treat was used for primary analyses.

resultsOf the 197 infants enrolled in the original study there were 15 deaths, 5 in the umbilical cord milking group and 10 in DCC group. Of the remaining infants, 135 (74%) were assessed at 22-26 months of corrected age. Demographics in umbilical cord milking (n = 70) and DCC (n = 65) groups were similar. Infants randomized to umbilical cord milking at birth had significantly higher cognitive and language composite scores, and were less likely to have a cognitive composite score of <85 (4% vs 15%; P = .04). Motor function was similar in both groups. There were no differences in the incidences of mild or moderate to severe neurodevelopmental impairment, hearing or visual impairments, pulmonary morbidities, or rehospitalizations between the 2 groups.

conclusionsInfants randomized to umbilical cord milking had higher language and cognitive scores compared with those randomized to DCC. There was no difference in rates of mild or moderate to severe neurodevelopmental impairment.

trial registrationclinicaltrials.gov: NCT01434732.

Indexed as

Child DevelopmentChild, PreschoolCognitionCohort StudiesFemaleHumansInfantInfant, NewbornInfant, PrematureMaleMotor ActivityTime FactorsUmbilical Cordintraventricular hemorrhageneonatalplacental transfusionresuscitation

Identifiers

PMID29246467
PMCPMC9442450

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.