ArticleThe Journal of pediatrics2018
Newborn Screening in the US May Miss Mild Persistent Hypothyroidism.
Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Clinical guideline of «congenital hypothyroidism»].Problemy endokrinologii · 2022Guideline
- Review
- Exploring reference ranges for thyroid-stimulating hormone in neonatal screening tests for preterm infants: a 5-year retrospective study.Frontiers in pediatrics · 2026Article
- A practical gestational age-based algorithm for timely detection of hypothyroidism in premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Newborn screening for primary congenital hypothyroidism: past, present and future.European thyroid journal · 2025Review
- Newborn screening for central congenital hypothyroidism: past, present and future.European thyroid journal · 2025Review
- Newborn screening for congenital hypothyroidism: worldwide coverage 50 years after its start.European thyroid journal · 2025Review
- Newborn screening and the screening laboratory: past, present and future.European thyroid journal · 2025Review
- Revealing the genotype-phenotype correlations of congenital hypothyroidism in Yunnan Province, Southwest China.Frontiers in endocrinology · 2025Article
- Associations between OGTT results during pregnancy and offspring TSH levels: a birth cohort study.BMC pregnancy and childbirth · 2024Article
- Neonatal screening for primary and central congenital hypothyroidism: is it time to go Dutch?European thyroid journal · 2023Review
- The Role of Iodine for Thyroid Function in Lactating Women and Infants.Endocrine reviews · 2022Review
- Preterm to term infant postmenstrual age reference intervals for thyroid-stimulating hormone and free thyroxine.Pediatric research · 2022Article
- Congenital Hypothyroidism in Preterm Newborns - The Challenges of Diagnostics and Treatment: A Review.Frontiers in endocrinology · 2022Review
- Follow-up study of preterm infants with thyroid dysfunction after medication.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Newborn Screening for Congenital Hypothyroidism-Clinical Evaluation and Comparison of Two Different Test Kits for the Determination of TSH in Dried Blood Samples on Two Different Platforms.International journal of neonatal screening · 2021Article
- Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV.Cell death discovery · 2021Article
- First Experiences with Newborn Screening for Congenital Hypothyroidism in Ulaanbaatar, Mongolia.International journal of neonatal screening · 2021Article
- Improving the Dutch Newborn Screening for Central Congenital Hypothyroidism by Using 95% Reference Intervals for Thyroxine-Binding Globulin.European thyroid journal · 2021Article
- Does Early Identification of Central Congenital Hypothyroidism Result in Improved Outcomes?The Journal of clinical endocrinology and metabolism · 2021Article
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5 authors.
Funding
Abstract
objectiveTo determine if newborn screening (NBS) programs for congenital hypothyroidism in the US use thyroid-stimulating hormone (TSH) cutoffs that are age adjusted to account for the physiologic 4-fold reduction in TSH concentrations over the first few days of life. STUDY
designAll NBS programs in the US were contacted and asked to provide information on their NBS protocols, TSH cutoffs, and whether these cutoffs were age adjusted.
resultsOf 51 NBS programs, 28 request a repeat specimen if the initial eluted serum TSH concentration is mildly increased (between the cutoff and a median upper limit of 50 mU/L), whereas 14 programs perform a routine second screen in all infants. Although these specimens are typically collected between 1 week and 1 month of life, 16 of the 28 programs with a discretionary second test and 8 of 14 programs with a routine second test do not have age-adjusted TSH cutoffs after the first 48 hours of life.
conclusionsThere is variation in NBS practices for screening for congenital hypothyroidism across the US, and many programs do not adjust the TSH cutoff beyond the first 2 days of life. Samples are processed when received from older infants, often to retest borderline initial results. This approach will miss congenital hypothyroidism in infants with persistent mild TSH elevations. We recommend that all NBS programs provide age-adjusted TSH cutoffs, and suggest developing a standard approach to screening for congenital hypothyroidism in the US.
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