Evidence map›Paper›PMID 29246338›Full record

ArticleThe Journal of pediatrics2018

Cardiorespiratory Capacity and Strength Remain Attenuated in Children with Severe Burn Injuries at Over 3 Years Postburn.

Janos Cambiaso-Daniel, Eric Rivas, Joshua S Carson, Gabriel Hundeshagen, Omar Nunez Lopez, Shauna Q Glover, David N Herndon, Oscar E Suman

Open access · greenAbstract read
In one paragraph

Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Key Exercise Concepts in the Rehabilitation from Severe Burns.Physical medicine and rehabilitation clinics of North America · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Rehabilitative Exercise Training for Burn Injury.Sports medicine (Auckland, N.Z.) · 2021
    Review
  11. Article
  12. Cardiovascular Effect of Varying Interval Training Frequency in Rehabilitation of Severely Burned Children.Journal of burn care & research : official publication of the American Burn Association · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Janos Cambiaso-DanielDepartment of Surgery, University of Texas Medical Branch, Galveston, TX; Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX; Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
Eric RivasDepartment of Surgery, University of Texas Medical Branch, Galveston, TX; Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX; Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, TX.
Joshua S CarsonShands Burn Center, Department of Surgery, University of Florida, Gainesville, FL.
Gabriel HundeshagenDepartment of Surgery, University of Texas Medical Branch, Galveston, TX; Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX; BG Trauma & Burn Center, Department of Hand, Plastic and Reconstructive Surgery, University of Heidelberg, Ludwigshafen, Germany.
Omar Nunez LopezDepartment of Surgery, University of Texas Medical Branch, Galveston, TX; Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX.
Shauna Q GloverDepartment of Surgery, University of Texas Medical Branch, Galveston, TX; Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX.
David N HerndonDepartment of Surgery, University of Texas Medical Branch, Galveston, TX; Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX.
Oscar E SumanDepartment of Surgery, University of Texas Medical Branch, Galveston, TX; Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX. Electronic address: ravi.jhaveri@unc.edu.
Shriners Hospitals for Children - Galveston · USHeidelberg University · DEMedical University of Graz · ATTexas Tech University · USUF Health Shands Hospital · US

Funding

Project 9: The role of androgen/corticosteroid in fat, muscle and glucose metabolism of burn victimsP50GM060338 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI HERNDON, DAVID N. · 2000 to 2017
$24.2M
MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSER01GM056687 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI HERNDON, DAVID N. · 1998 to 2017
$9.0M
Oxandrolone and Exercise: A potent therapy in the rehabilitation from burnsR01HD049471 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUMAN-VEJAS, OSCAR E. · 2006 to 2019
$5.8M
POSTDOCTORAL TRAINING IN TRAUMA &BURNST32GM008256 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Celeste Campbell Finnerty, Oscar E. Suman-Vejas · 1990 to 2026
$4.0M
NICHD NIH HHS R01 HD049471NIGMS NIH HHS P50 GM060338NIGMS NIH HHS R01 GM056687NIGMS NIH HHS T32 GM008256
6 · The paper itself

Abstract

objectivesTo compare physical capacity and body composition between children with burn injuries at approximately 4 years postburn and healthy, fit children. STUDY

designIn this retrospective, case-control study, we analyzed the strength, aerobic capacity, and body composition of children with severe burn injuries (n = 40) at discharge, after completion of a 6- to 12-week rehabilitative exercise training program, and at 3-4 years postburn. Values were expressed as a relative percentage of those in age- and sex-matched children for comparison (n = 40 for discharge and postexercise; n = 40 for 3.5 years postburn).

resultsAt discharge, lean body mass was 89% of that in children without burn injuries, and exercise rehabilitation restored this to 94% (P < .01). At 3.5 years postburn, lean body mass (94%), bone mineral content (89%), and bone mineral density (93%; each P ≤ .02) remained reduced, whereas total body fat was increased (148%, P = .01). Cardiorespiratory fitness remained lower in children with burn injuries both after exercise training (75%; P < .0001) and 3.5 years later (87%; P < .001). Peak torque (60%; P < .0001) and average power output (58%; P < .0001) were lower after discharge. Although exercise training improved these, they failed to reach levels achieved in healthy children without burns (83-84%; P < .0001) but were maintained at 85% and 82%, respectively, 3.5 years later (P < .0001).

conclusionsAlthough the benefits of rehabilitative exercise training on strength and cardiorespiratory capacity are maintained at almost 4 years postburn, they are not restored fully to the levels of healthy children. Although the underlying mechanism of this phenomenon remains elusive, these findings suggest that future development of continuous exercise rehabilitation interventions after discharge may further narrow the gap in relation to healthy adolescents.

Indexed as

Body CompositionCardiorespiratory FitnessExercise ToleranceMuscle StrengthAdolescentBurnsCase-Control StudiesChildExercise TherapyFemaleFollow-Up StudiesHumansMaleRetrospective StudiesTreatment Outcomebody compositionexercise programmuscle strengthpeak aerobic capacityrehabilitationstandard of care

Identifiers

PMID29246338
PMCPMC5739078
OpenAlexW2773581809

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.