ArticleArthritis research & therapy2017
Factors associated with the 6-minute walk distance in patients with systemic sclerosis.
Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Survival and prognosis factors in systemic sclerosis: data of a French multicenter cohort, systematic review, and meta-analysis of the literature.Arthritis research & therapy · 2019Pooled it
- Factors associated with variations in the 6-minute walk distance during the follow-up of patients with systemic sclerosis.Arthritis research & therapy · 2026Article
- Ventilatory inefficiency limits 6-min walked distance in systemic sclerosis-associated interstitial lung disease.Scientific reports · 2025Article
- Article
- Divergent perspectives: exploring the relationships between St. George's Respiratory Questionnaire and outcome measures in systemic sclerosis-associated interstitial lung disease.Clinical rheumatology · 2024Article
- Functional capacity, physical activity, and arterial stiffness in patients with systemic sclerosis.Clinical rheumatology · 2024Article
- Validity and reliability of measurement of peripheral oxygen saturation during the 6-Minute Walk Test in patients with systemic sclerosis.Rheumatology international · 2024Article
- Comparison of physiological responses after incremental shuttle walking test and 6-minute walk test in patients with systemic sclerosis.Wiener klinische Wochenschrift · 2024Article
- Determinants of Six-Minute Walk Test Performance in Women with Systemic Sclerosis.Journal of musculoskeletal & neuronal interactions · 2023Article
- Characteristics of ScleroID highlighting musculoskeletal and internal organ implications in patients afflicted with systemic sclerosis.Arthritis research & therapy · 2023Article
- Clinical associations and prognostic implications of 6-minute walk test in rheumatoid arthritis.Scientific reports · 2022Article
- The 6-min walk test as a primary end-point in interstitial lung disease.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Paraclinical Aspects in Systemic Sclerosis.International journal of general medicine · 2022Review
- Patient-centered Outcomes Research in Interstitial Lung Disease: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2021Article
- Autoimmune Progressive Fibrosing Interstitial Lung Disease: Predictors of Fast Decline.Frontiers in pharmacology · 2021Article
- Lack of association between six-minute walk distance and pulmonary artery pressure in patients with systemic sclerosis and cardiopulmonary symptoms.Journal of cardiovascular and thoracic research · 2020Article
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Authors and funding
16 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is an ongoing debate regarding the relevance of the 6-minute walking distance (6MWD) in systemic sclerosis (SSc) assessment, widely used as a usual test in these patients as well as an outcome measure in clinical trials. In this work, we aimed to assess the associations between the 6MWD and various disease parameters in patients with SSc.
methodsConsecutive patients followed in our SSc National Reference Centre were included in this cross-sectional study if they fulfilled the 2013 American College of Rheumatology/European League Against Rheumatism criteria for SSc. Data were systematically collected during a comprehensive standardized evaluation that included a 6-minute walk test, clinical assessment, biological results, pulmonary function tests, transthoracic echocardiography, composite scores (European Scleroderma Study Group Activity Index, Medsger severity score, Health Assessment Questionnaire-Disability Index (HAQ-DI)) and treatments. Associations of the 6MWD with various disease parameters were assessed by linear regression in univariate and multivariate analyses.
resultsThe study population comprised 298 patients (females 81%; mean age 58.2 ± 13.3 years; limited cutaneous SSc 82%; interstitial lung disease (ILD) 42%; pulmonary arterial hypertension (PAH) 6%). The 6MWD was significantly and independently associated with gender, age, body mass index, baseline heart rate (HR), HR variation during the test, PAH, history of arterial thrombosis and C-reactive protein levels, as well as with the HAQ-DI score in a sensitivity analysis. Muscle involvement, joint involvement and ILD were not independently associated with the 6MWD.
conclusionsDuring SSc, the 6MWD is independently associated with initial HR and HR variation; with PAH but not ILD, suggesting that pulmonary vasculopathy may have a greater impact than parenchymal involvement on functional limitation; and with global markers of disease activity and patient disability. These results give clinicians further insight into how to interpret the 6MWD in the context of SSc.
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