ArticleBMC genomics2017
Bioinformatically predicted deleterious mutations reveal complementation in the interior spruce hybrid complex.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 53 citations in OpenAlex.
- Genomic and environmental influences on resilience in a cold-water fish near the edge of its range.Evolutionary applications · 2021Article
- Purifying selection shaping the evolution of the Toll-like receptor 2 TIR domain in brown hares (Lepus europaeus) from Europe and the Middle East.Molecular biology reports · 2020Article
- 275 years of forestry meets genomics inEvolutionary applications · 2020Review
- Somatic mutations substantially increase the per-generation mutation rate in the coniferEvolution letters · 2019Article
- Purifying selection does not drive signatures of convergent local adaptation of lodgepole pine and interior spruce.BMC evolutionary biology · 2019Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMutation load is expected to be reduced in hybrids via complementation of deleterious alleles. While local adaptation of hybrids confounds phenotypic tests for reduced mutation load, it may be possible to assess variation in load by analyzing the distribution of putatively deleterious alleles. Here, we use this approach in the interior spruce (Picea glauca x P. engelmannii) hybrid complex, a group likely to suffer from high mutation load and in which hybrids exhibit local adaptation to intermediate conditions. We used PROVEAN to bioinformatically predict whether non-synonymous alleles are deleterious, based on conservation of the position and abnormality of the amino acid change.
resultsAs expected, we found that predicted deleterious alleles were at lower average allele frequencies than alleles not predicted to be deleterious. We were unable to detect a phenotypic effect on juvenile growth rate of the many rare alleles predicted to be deleterious. Both the proportion of alleles predicted to be deleterious and the proportion of loci homozygous for predicted deleterious alleles were higher in P. engelmannii (Engelmann spruce) than in P. glauca (white spruce), due to higher diversity and frequencies of rare alleles in Engelmann. Relative to parental species, the proportion of alleles predicted to be deleterious was intermediate in hybrids, and the proportion of loci homozygous for predicted deleterious alleles was lowest.
conclusionGiven that most deleterious alleles are recessive, this suggests that mutation load is reduced in hybrids due to complementation of deleterious alleles. This effect may enhance the fitness of hybrids.
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