Evidence map›Paper›PMID 29246155›Full record

ArticleJournal of nanobiotechnology2017

ZnO nanoparticles modulate the ionic transport and voltage regulation of lysenin nanochannels.

Sheenah L Bryant, Josh E Eixenberger, Steven Rossland, Holly Apsley, Connor Hoffmann, Nisha Shrestha, Michael McHugh, Alex Punnoose, Daniel Fologea

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Susceptibility of the Oral Commensal BacteriumInternational journal of molecular sciences · 2026
    Article
  2. Lysenin Channels as Sensors for Ions and Molecules.Sensors (Basel, Switzerland) · 2020
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sheenah L BryantDepartment of Physics, Boise State University, Boise, ID, 83725, USA.
Josh E EixenbergerDepartment of Physics, Boise State University, Boise, ID, 83725, USA.
Steven RosslandDepartment of Physics, Boise State University, Boise, ID, 83725, USA.
Holly ApsleyDepartment of Physics, Boise State University, Boise, ID, 83725, USA.
Connor HoffmannDepartment of Physics, Boise State University, Boise, ID, 83725, USA.
Nisha ShresthaDepartment of Physics, Boise State University, Boise, ID, 83725, USA.
Michael McHughDepartment of Physics, Boise State University, Boise, ID, 83725, USA.
Alex PunnooseDepartment of Physics, Boise State University, Boise, ID, 83725, USA.
Daniel FologeaDepartment of Physics, Boise State University, Boise, ID, 83725, USA. DanielFologea@boisestate.edu.ORCID http://orcid.org/0000-0002-9179-7574

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Carolyn Hovde Bohach · 2012 to 2026
$59.8M
VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI OXFORD, JULIA THOM · 2014 to 2023
$22.7M
NASA NNX15AU64HNIGMS NIH HHS P20 GM103408NIGMS NIH HHS P20 GM109095NIH HHS P20GM103408NIH HHS P20GM109095
6 · The paper itself

Abstract

backgroundThe insufficient understanding of unintended biological impacts from nanomaterials (NMs) represents a serious impediment to their use for scientific, technological, and medical applications. While previous studies have focused on understanding nanotoxicity effects mostly resulting from cellular internalization, recent work indicates that NMs may interfere with transmembrane transport mechanisms, hence enabling contributions to nanotoxicity by affecting key biological activities dependent on transmembrane transport. In this line of inquiry, we investigated the effects of charged nanoparticles (NPs) on the transport properties of lysenin, a pore-forming toxin that shares fundamental features with ion channels such as regulation and high transport rate.

resultsThe macroscopic conductance of lysenin channels greatly diminished in the presence of cationic ZnO NPs. The inhibitory effects were asymmetrical relative to the direction of the electric field and addition site, suggesting electrostatic interactions between ZnO NPs and a binding site. Similar changes in the macroscopic conductance were observed when lysenin channels were reconstituted in neutral lipid membranes, implicating protein-NP interactions as the major contributor to the reduced transport capabilities. In contrast, no inhibitory effects were observed in the presence of anionic SnO

conclusionWe conclude that electrostatic interactions between positively charged ZnO NPs and negative charges within the lysenin channels are responsible for the inhibitory effects on the transport of ions. These interactions point to a potential mechanism of cytotoxicity, which may not require NP internalization.

Indexed as

Electric ConductivityIon Channel GatingLipid BilayersMetal NanoparticlesTin CompoundsToxins, BiologicalZinc OxideLipid Bilayerslyseninstannic oxideTin CompoundsToxins, BiologicalZinc OxideElectrophysiologyIon transportLigand gated channelsLyseninNanoparticlesSnO2ToxicityVoltage gated channelsZnO

Identifiers

PMID29246155
PMCPMC5732404

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.