Observational studyBMC musculoskeletal disorders2017
Association between metabolic syndrome and knee osteoarthritis: a cross-sectional study.
Observational study in BMC musculoskeletal disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06611774 (Metabolic Syndrome in Patients with Knee Osteoarthritis), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolic Syndrome in Patients with Knee Osteoarthritis
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Metabolic syndrome, hypertension, and hyperglycemia were positively associated with knee osteoarthritis, while dyslipidemia showed no association with knee osteoarthritis.Clinical rheumatology · 2021Pooled it
- Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis.BioMed research international · 2020Pooled it
- Knee Osteoarthritis and Metabolic Disorders: Practical Aspects from Primary Healthcare.Journal of clinical medicine · 2026Article
- Association of blood pressure with knee pain progression over 4 years in middle-aged and elderly individuals with or at risks for osteoarthritis: data from the Osteoarthritis Initiative.Clinical rheumatology · 2026Article
- Metabolic syndrome is associated with more pain in hand osteoarthritis: Results from the DIGICOD cohort.Osteoarthritis and cartilage open · 2025Article
- Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis.Journal of inflammation research · 2025Review
- Comparison of Gait in Women with Degenerative Changes of the Hip Joint and Healthy Women Using the MoKA System-A Pilot Study.Sensors (Basel, Switzerland) · 2024Article
- Novel insights into the role of metabolic disorder in osteoarthritis.Frontiers in endocrinology · 2024Review
- Metabolic syndrome and the likelihood of knee pain and functional disability: evidence from a large middle eastern population-based study.BMC musculoskeletal disorders · 2023Article
- Factors Associated with Osteoarthritis and Their Influence on Health-Related Quality of Life in Older Adults with Osteoarthritis: A Study Based on the 2020 Korea National Health and Nutrition Examination Survey.International journal of environmental research and public health · 2023Article
- Osteoarthritis and Diabetes: Where Are We and Where Should We Go?Diagnostics (Basel, Switzerland) · 2023Review
- Wnt signalling in the articular cartilage: A matter of balance.International journal of experimental pathology · 2023Review
- Association of a femoral neck T score with knee joint osteophyte formation but not with skeletal muscle mass.Clinical rheumatology · 2023Article
- Do Individualized Patient-Specific Situations Predict the Progression Rate and Fate of Knee Osteoarthritis? Prediction of Knee Osteoarthritis.Journal of clinical medicine · 2023Article
- Leptin and interleukin-1β levels associated with osteoarthritis in Vietnamese patients: a cross-sectional analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
- Colchicine versus Physical Therapy in Knee Osteoarthritis.Life (Basel, Switzerland) · 2022Article
- Article
- The Impact of Metabolic Syndrome on Quality of Life Among Individuals With Knee Osteoarthritis Living in Egypt.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2022Article
- Article
- Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundOsteoarthritis (OA) is the most prevalent chronic joint disease in China. The aim of this study was to examine the association between metabolic syndrome (MetS) and knee OA in a population-based Chinese study.
methodsData included in this analysis is from a cross-sectional study, i.e., the Xiangya Hospital Health Management Center Study. MetS was diagnosed according to the criteria defined by the Chinese Diabetes Society. Radiographic knee OA was defined as changes equivalent to Kellgren-Lawrence (K-L) grade 2 or above at least one side. Associations between MetS and its components with OA were evaluated by conducting multivariable adjusted logistic regression.
resultsA total of 5764 participants were included in the present study. The unadjusted OR (1.27, 95%CI: 1.10-1.47, P = 0.001), age-sex adjusted OR (1.17, 95%CI: 1.01-1.36, P = 0.041) and multivariable adjusted OR (1.17, 95%CI: 1.01-1.36, P = 0.043) all suggested a positive association between MetS and knee OA. Besides, its components (e.g., overweight, hypertension and dyslipidemia) were also associated with the prevalence of radiographic knee OA respectively, after adjusting for some confounding factors. In addition, with the accumulation of MetS components, the prevalence of knee OA increased. Furthermore, MetS as a whole was associated with the prevalence of knee osteophyte (OSP) (OR = 1.72, 95%CI: 1.42-2.09, P < 0.001), but not joint space narrowing (JSN) (OR = 1.06, 95%CI: 0.91-1.23, P = 0.449).
conclusionsThe findings of the present study indicated that there was a positive association between the prevalence of MetS and knee OA. However, MetS as a whole was associated with the higher prevalence of knee OSP, but not JSN, which should shed light on our understanding the association between MetS and OA.
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