Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study.

Azza Mohamed Ahmed Said, Ahmed Mohamed Elbayomi, Ashraf Abdelsalam Kandeel Shaat

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Article in BMC ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

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2citing papers in PubMed, 1 pooled it

0.5field-weighted citation impact, top 32% of its field

1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility.Medicine · 2018
Pooled it
Quantitative evaluation of retinal microvasculature and retrobulbar vessels after intravenous chemotherapy for retinoblastoma.BMC ophthalmology · 2021
Article

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5 · Who and what money

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3 authors at 1 institution in 1 country.

Azza Mohamed Ahmed SaidOphthalmology Department, Faculty of Medicine, Ain Shams University, Corresponding author address: 10 th Fawzy Elmoteay street, Heliopolis, Cairo, Postal code: 11736, Egypt. dr_azza_22@hotmail.com.

Ahmed Mohamed ElbayomiOphthalmology Department, Faculty of Medicine, Ain Shams University, Corresponding author address: 10 th Fawzy Elmoteay street, Heliopolis, Cairo, Postal code: 11736, Egypt.

Ashraf Abdelsalam Kandeel ShaatOphthalmology Department, Faculty of Medicine, Ain Shams University, Corresponding author address: 10 th Fawzy Elmoteay street, Heliopolis, Cairo, Postal code: 11736, Egypt.

Ain Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo describe objectively the possible structural changes of the macula and optic nerve head in the free eyes of unilateral cured retinoblastoma patients and, also after enucleation using spectral domain optical coherence tomography.

methodsA cross sectional study involving 60 patients subdivided into three groups; 15 unilateral RB patients in whom enucleation was indicated as a sole treatment performed earlier in life [(study group (I)], 15 unilateral RB patients who had completely regressed disease with a preserved eye [(study group (II)] and 30 age and sex matched healthy controls. The remaining and free eyes in study groups and right eyes of control group had full ophthalmological examination, static automated perimetry and optical coherence tomography of the macula and optic nerve head.

resultsIn study group (II); a significant thinning of total macula, central fovea, ganglion cell layer (GCL), ganglion cell complex (GCC), and some sectors of outer nuclear layer (P- values ≤0.05) was found with no significant difference in peripapillary nerve fiber layer (pRNFL) thickness and optic nerve head parameters compared to the control group and the study group (I). A significantly thickened total macula, GCL, GCC, and pRNFL in study group (I) compared to study group (II). Thickened pRNFL was significantly correlated to standard automated perimetry pattern deviations. No significant difference was found between study group (I) and control group.

conclusionRetinoblastoma eyes characterized by thinning of central fovea, GCL, GCC compared to the control group. After unilateral enucleation, increased GCC and pRNFL thicknesses were detected compared to retinoblastoma group.

Indexed as

Eye EnucleationAdolescentAdultCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesFemaleHumansMacula LuteaMaleNerve FibersOptic DiskRetinal Ganglion CellsRetinal NeoplasmsRetinoblastomaEnucleationGanglion cell complexPeripapillary nerve fiber layerRetinoblastoma

Identifiers

PMID29246122

DOI10.1186/s12886-017-0650-9

PMCPMC5732405

OpenAlexW2774920796

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.