Evidence map›Paper›PMID 29245898›Full record

ArticleOncotarget2017

A novel small-molecule arylsulfonamide causes energetic stress and suppresses breast and lung tumor growth and metastasis.

Xin Dai, Stefan Kaluz, Ying Jiang, Lei Shi, DeAngelo Mckinley, Yingzhe Wang, Binghe Wang, Erwin G Van Meir, Chalet Tan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Xin DaiDepartment of Pharmaceutics and Drug Delivery, University of Mississippi, Oxford, MS, USA.
Stefan KaluzDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Ying JiangDepartment of Pharmaceutical Sciences, Mercer University, Atlanta, GA, USA.
Lei ShiDepartment of Biology, Georgia State University, Atlanta, GA, USA.
DeAngelo MckinleyDepartment of Pharmaceutical Sciences, Mercer University, Atlanta, GA, USA.
Yingzhe WangDepartment of Pharmaceutical Sciences, Mercer University, Atlanta, GA, USA.
Binghe WangDepartment of Chemistry, Georgia State University, Atlanta, GA, USA.
Erwin G Van MeirDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Chalet TanDepartment of Pharmaceutics and Drug Delivery, University of Mississippi, Oxford, MS, USA.
Mercer University · USEmory University · USGeorgia State University · USUniversity of Mississippi · US

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
Targeting Glioblastoma Using Novel Small Molecule HIF-1 Pathway InhibitorsR01CA116804 · NCI · EMORY UNIVERSITY · PI VAN MEIR, ERWIN G. · 2007 to 2011
$2.5M
Mechanisms of Action for KCN1 in the Control of Uveal Melanoma MetastasisR01CA176001 · NCI · EMORY UNIVERSITY · PI GROSSNIKLAUS, HANS E., VAN MEIR, ERWIN G. · 2014 to 2018
$1.7M
Discovery of chemical probes for uveal melanomaR01CA180805 · NCI · EMORY UNIVERSITY · PI GROSSNIKLAUS, HANS E., VAN MEIR, ERWIN G. · 2013 to 2015
$1.6M
NCI NIH HHS P30 CA138292NCI NIH HHS R01 CA116804NCI NIH HHS R01 CA176001NCI NIH HHS R01 CA180805
6 · The paper itself

Abstract

Neoplastic cells display reprogrammed metabolism due to the heightened energetic demands and the need for biomass synthesis of a growing tumor. Targeting metabolic vulnerabilities is thus an important goal for cancer therapy. Here, we describe a novel small-molecule arylsulfonamide (N-cyclobutyl-N-((2,2-dimethyl-2

Indexed as

AMPKarylsulfonamideHIF-1metastasismTORC1

Identifiers

PMID29245898
PMCPMC5725089
OpenAlexW2765678737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.