Evidence map›Paper›PMID 29245897›Full record

ArticleOncotarget2017

Comparative analysis of primary

Danielle M Greenawalt, Winnie S Liang, Sakina Saif, Justin Johnson, Petar Todorov, Austin Dulak, Daniel Enriquez, Rebecca Halperin, Ambar Ahmed, Vladislav Saveliev and 8 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. RHOA controls oncogenic B cell receptor signaling in aggressive lymphoma.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. A proof of concept study ofScientific reports · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Genetic alterations and their clinical implications in DLBCL.Nature reviews. Clinical oncology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Danielle M GreenawaltOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
Winnie S LiangTranslational Genomics Research Institute, Phoenix AZ, USA.
Sakina SaifOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
Justin JohnsonOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
Petar TodorovOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
Austin DulakOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
Daniel EnriquezTranslational Genomics Research Institute, Phoenix AZ, USA.
Rebecca HalperinTranslational Genomics Research Institute, Phoenix AZ, USA.
Ambar AhmedOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
Vladislav SavelievCenter for Algorithmic Biotechnology, Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
John CarptenTranslational Genomics Research Institute, Phoenix AZ, USA.
David CraigTranslational Genomics Research Institute, Phoenix AZ, USA.
J Carl BarrettOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
Brian DoughertyOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
Michael ZindaOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
Stephen FawellOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
Jonathan R DryOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
Kate BythOncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA.
AstraZeneca (United States) · USTranslational Genomics Research Institute · USSt Petersburg University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current understanding of the mutation spectrum of relapsed/refractory (RR) tumors is limited. We performed whole exome sequencing (WES) on 47 diffuse large B cell lymphoma (DLBCL) tumors that persisted after R-CHOP treatment, 8 matched to primary biopsies. We compared genomic alterations from the RR cohort against two treatment-naïve DLBCL cohorts (n=112). While the overall number and types of mutations did not differ significantly, we identified frequency changes in DLBCL driver genes. The overall frequency of

Indexed as

DLBCLmutationNGSR-CHOPresistance

Identifiers

PMID29245897
PMCPMC5725088
OpenAlexW2626615329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.