ArticleEnvironmental research2018
Bisphenol and phthalate concentrations and its determinants among pregnant women in a population-based cohort in the Netherlands, 2004-5.
Article in Environmental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
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Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- An Evaluation of Food and Nutrient Intake among Pregnant Women in The Netherlands: A Systematic Review.Nutrients · 2023Pooled it
- Food Consumption, Nutrient Intake and Status during the First 1000 days of Life in the Netherlands: a Systematic Review.Nutrients · 2019Pooled it
- Prenatal and childhood exposure to common plasticizers and risk-taking behavior in young adolescents.Environmental research · 2026Article
- Associations of Exposure to Common Plasticizers and Organophosphate Pesticides during Pregnancy and in Childhood with Cognitive Performance in Adolescents: A Population-Based Study.Environmental science & technology · 2026Article
- Prenatal and childhood exposure to common plasticizers in relation to emotional and behavioral development through adolescence.The Science of the total environment · 2026Article
- Placental angiogenic biomarkers in relation to prenatal bisphenol and phthalate exposure.Placenta · 2026Article
- Semi-automated, evidence-based workflow for selection of reference chemicals for the validation of NAMs: a case study with the adipogenesis assay.NAM journal · 2026Article
- [Determination of 17 bisphenol compounds in human urine by solid supported liquid-liquid extraction-ultra-high performance liquid chromatography-tandem mass spectrometry].Se pu = Chinese journal of chromatography · 2025Article
- Periconception bisphenol and phthalate concentrations in women and men, time to pregnancy, and risk of miscarriage.Environmental research · 2025Article
- The deleterious effect of bisphenol S on early embryo development of mice.Hormones (Athens, Greece) · 2025Article
- Article
- Association between serum and red blood cell folate concentrations and urinary phthalate metabolite concentrations in US adults: evidence from a large population-based study.Frontiers in nutrition · 2025Article
- Sex-Specific Associations between Prenatal Exposure to Bisphenols and Phthalates and Infant Epigenetic Age Acceleration.Epigenomes · 2024Article
- Associations of bisphenol and phthalate exposure and anti-Müllerian hormone levels in women of reproductive age.EClinicalMedicine · 2024Article
- Prenatal phthalate exposure and adverse birth outcomes in the USA: a prospective analysis of births and estimates of attributable burden and costs.The Lancet. Planetary health · 2024Article
- Plastics in human diets: development and evaluation of the 24-h Dietary Recall - Plastic Exposure and the Dietary Plastics Score.Frontiers in nutrition · 2024Article
- Prenatal exposure to common plasticizers: a longitudinal study on phthalates, brain volumetric measures, and IQ in youth.Molecular psychiatry · 2023Article
- Characterizing changes in behaviors associated with chemical exposures during the COVID-19 pandemic.PloS one · 2023Article
- Bisphenol A substitutes and obesity: a review of the epidemiology and pathophysiology.Frontiers in endocrinology · 2023Review
- Associations of Early Pregnancy Metabolite Profiles with Gestational Blood Pressure Development.Metabolites · 2022Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundExposure to bisphenols and phthalates in pregnancy may lead to adverse health effects in women themselves and their offspring.
objectiveTo describe first trimester bisphenol and phthalate urine concentrations, including bisphenol and phthalate replacements, and determine nutritional, socio-demographic and lifestyle related determinants.
methodsIn a population-based prospective cohort of 1396 mothers, we measured first trimester bisphenol, phthalate and creatinine urine concentrations (samples collected in 2004-2005, median gestational age 12.9 weeks [inter-quartile range (IQR) 12.1-14.4]). We examined associations of potential determinants with log-transformed bisphenol and phthalate concentrations. Outcomes were back-transformed. Nutritional analyses were performed in a subgroup of 642 Dutch participants only, as the Food Frequency Questionnaire was aimed at Dutch food patterns.
resultsBisphenol A, bisphenol S, and bisphenol F were detected in 79.2%, 67.8% and 40.2% of the population, respectively. Mono-n-butylphthalate, mono-(2-ethyl-5-hydroxyhexyl)phthalate and monobenzylphthalate were detected in > 90% of the population. Nutritional intake was not associated with bisphenol and phthalate concentrations after correction for multiple testing was applied. Obesity was associated with higher high-molecular-weight phthalate concentrations and the lack of folic acid supplement use with higher di-n-octylphthalate concentrations (respective mean differences were 46.73nmol/l [95% CI 14.56-93.72] and 1.03nmol/l [0.31-2.06]).
conclusionBisphenol S and F exposure was highly prevalent in pregnant women in the Netherlands as early as 2004-5. Although associations of dietary and other key factors with bisphenol and phthalate concentrations were limited, adverse lifestyle factors including obesity and the lack of folic acid supplement use seem to be associated with higher phthalate concentrations in pregnant women. The major limitation was the availability of only one urine sample per participant. However, since phthalates are reported to be quite stable over time, results concerning determinants of phthalate concentrations are expected to be robust.
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